Thirty quinoxalines bearing a substituted anilino group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl group on position 6 or 7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10-5and 10-4molar concentrations. Interesting selectivities were also recorded between 10-8and 10-6M for a few compounds. One single compound exhibited good activity against Candida Albicans.

Quinoxaline chemistry. Part 8. 2-[anilino]-3- [carboxy]-6(7)-substituted quinoxalines as non classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activityIn: IL FARMACO. - ISSN 0014-827X. - 52:8-9(1997), pp. 531-537.

Quinoxaline chemistry. Part 8. 2-[anilino]-3- [carboxy]-6(7)-substituted quinoxalines as non classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activity

Loriga, Mario;Paglietti, Giuseppe;Zanetti, Stefania Anna Lucia
1997

Abstract

Thirty quinoxalines bearing a substituted anilino group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl group on position 6 or 7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10-5and 10-4molar concentrations. Interesting selectivities were also recorded between 10-8and 10-6M for a few compounds. One single compound exhibited good activity against Candida Albicans.
Quinoxaline chemistry. Part 8. 2-[anilino]-3- [carboxy]-6(7)-substituted quinoxalines as non classical antifolate agents. Synthesis and evaluation of in vitro anticancer, anti-HIV and antifungal activityIn: IL FARMACO. - ISSN 0014-827X. - 52:8-9(1997), pp. 531-537.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/263475
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