Forty amides, formamidines and trifluoromethylsulfonylamides bearing on the nitrogen a cyclohexyl residue, eventually 2-substituted, were prepared and tested for analgesic activity against a chemical stimulus. Good activity was exhibited by amides 9, 11 and 28, by formamidine 34, as well as by triflyamide 40. Eleven additional compounds exhibited a moderate activity.
Amides and formamidines with antinociceptive activity: note II / Boatto, Gianpiero; Palomba, Michele Francesco Luigi; Sparatore, Fabio; Pau, Amedeo; Varoni, Maria Vittoria; Cerri, Riccardo; Nicolai, Marco. - In: IL FARMACO. - ISSN 0014-827X. - 48:9(1993), pp. 1291-1299.
Amides and formamidines with antinociceptive activity: note II
Boatto, Gianpiero;Palomba, Michele Francesco Luigi;Pau, Amedeo;Varoni, Maria Vittoria;Cerri, Riccardo;Nicolai, Marco
1993-01-01
Abstract
Forty amides, formamidines and trifluoromethylsulfonylamides bearing on the nitrogen a cyclohexyl residue, eventually 2-substituted, were prepared and tested for analgesic activity against a chemical stimulus. Good activity was exhibited by amides 9, 11 and 28, by formamidine 34, as well as by triflyamide 40. Eleven additional compounds exhibited a moderate activity.| File | Dimensione | Formato | |
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