A convenient synthesis of tricyclic β-lactams by chemo- and diastereoselective intramolecular CH insertion of metal carbenes generated by dirhodium(II) tetraacetate catalyzed decomposition of α-diazoamides 1a-c is reported. In the case of reagent 1b, in the presence of the (+)-menthyl chiral auxiliary, the β-lactam is obtained with 76% e.e.
Quinoline beta-lactams by Rh(II)-catalyzed highly steroselective intramolecular carbene insertion into a carbon-hydrogen bond / Muroni, Daniele; Saba, Antonio. - 13:(2005), pp. 1-7.
Quinoline beta-lactams by Rh(II)-catalyzed highly steroselective intramolecular carbene insertion into a carbon-hydrogen bond
Muroni, Daniele;Saba, Antonio
2005-01-01
Abstract
A convenient synthesis of tricyclic β-lactams by chemo- and diastereoselective intramolecular CH insertion of metal carbenes generated by dirhodium(II) tetraacetate catalyzed decomposition of α-diazoamides 1a-c is reported. In the case of reagent 1b, in the presence of the (+)-menthyl chiral auxiliary, the β-lactam is obtained with 76% e.e.File in questo prodotto:
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