A convenient synthesis of tricyclic β-lactams by chemo- and diastereoselective intramolecular CH insertion of metal carbenes generated by dirhodium(II) tetraacetate catalyzed decomposition of α-diazoamides 1a-c is reported. In the case of reagent 1b, in the presence of the (+)-menthyl chiral auxiliary, the β-lactam is obtained with 76% e.e.
Quinoline beta-lactams by Rh(II)-catalyzed highly steroselective intramolecular carbene insertion into a carbon-hydrogen bond / Muroni, Daniele; Saba, Antonio. - 13:(2005), pp. 1-7.
Quinoline beta-lactams by Rh(II)-catalyzed highly steroselective intramolecular carbene insertion into a carbon-hydrogen bond
Muroni, Daniele;Saba, Antonio
2005-01-01
Abstract
A convenient synthesis of tricyclic β-lactams by chemo- and diastereoselective intramolecular CH insertion of metal carbenes generated by dirhodium(II) tetraacetate catalyzed decomposition of α-diazoamides 1a-c is reported. In the case of reagent 1b, in the presence of the (+)-menthyl chiral auxiliary, the β-lactam is obtained with 76% e.e.File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
Muroni_D_Articolo_2005_Quinoline.pdf
accesso aperto
Tipologia:
Versione editoriale (versione finale pubblicata)
Licenza:
Non specificato
Dimensione
164.3 kB
Formato
Adobe PDF
|
164.3 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
