Many viral pathogens encode the motor proteins named RNA helicases which display various functions in genome replication. General strategies to design specific and selective drugs targeting helicase for the treatment of viral infections could actviaone or more of the following mechanisms: inhibition of the NTPase activity, by interferences with ATP binding and therefore by limiting the energy required for the unwinding and translocation, or by allosteric mechanism and therefore by stabilizing the conformation of the enzyme in low helicase activity state; inhibition of nucleic acids binding to the helicase; inhibition of coupling of ATP hydrolysis to unwinding; inhibition of unwinding by sterically blocking helicase translocation. Recently, byin vitroscreening studies, it has been reported that several benzotriazole, imidazole, imidazodiazepine, phenothiazine, quinoline, anthracycline, triphenylmethane, tropolone, pyrrole, acridone, small peptide, and Bananin derivatives are endowed with helicase inhibition of pathogen viruses belonging toFlaviviridae,Coronaviridae, andPicornaviridaefamilies.
Inhibition of RNA helicases of ssRNA+virus belonging toFlaviviridae,CoronaviridaeandPicornaviridaefamilies / Piras, Sandra; Corona, Paola; Carta, Antonio; Briguglio, Irene. - 2011:(2011), pp. 1-22. [10.1155/2011/213135]
Inhibition of RNA helicases of ssRNA+virus belonging toFlaviviridae,CoronaviridaeandPicornaviridaefamilies
Piras, Sandra;Corona, Paola;Carta, Antonio;Briguglio, Irene
2011-01-01
Abstract
Many viral pathogens encode the motor proteins named RNA helicases which display various functions in genome replication. General strategies to design specific and selective drugs targeting helicase for the treatment of viral infections could actviaone or more of the following mechanisms: inhibition of the NTPase activity, by interferences with ATP binding and therefore by limiting the energy required for the unwinding and translocation, or by allosteric mechanism and therefore by stabilizing the conformation of the enzyme in low helicase activity state; inhibition of nucleic acids binding to the helicase; inhibition of coupling of ATP hydrolysis to unwinding; inhibition of unwinding by sterically blocking helicase translocation. Recently, byin vitroscreening studies, it has been reported that several benzotriazole, imidazole, imidazodiazepine, phenothiazine, quinoline, anthracycline, triphenylmethane, tropolone, pyrrole, acridone, small peptide, and Bananin derivatives are endowed with helicase inhibition of pathogen viruses belonging toFlaviviridae,Coronaviridae, andPicornaviridaefamilies.File | Dimensione | Formato | |
---|---|---|---|
Briguglio_I_Inhibition_of_RNA_helicases.pdf
accesso aperto
Tipologia:
Versione editoriale (versione finale pubblicata)
Licenza:
Creative commons
Dimensione
2.75 MB
Formato
Adobe PDF
|
2.75 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.