Two new cyclopentenylethylamines were prepared and were submitted to a pharmacological screening together with some others previously described and now reprepared. All compounds exhibited different degrees of depressive activity on CNS and good analgesic activity. Compound 5, bearing a phenyl group on the carbon atom to which the amino group is connected, appears rather interesting being the most active as analgesic and the least toxic. Compounds 2 and 3 are able to antagonize in a certain degree lethal doses of physostigmine and also, respectively, of pentylenetetrazole and strychnine.
Cyclopentenyl ethylamines active on CNS / Peana, Alessandra Tiziana; Pirisino, Gerolamo Antonio; Moretti, Mario Domenico Luigi; Dimich, P. M.; Satta, Margherita; Mulè, Antonio Calogero; Sparatore, Fabio. - In: IL FARMACO. - ISSN 0014-827X. - 47:9(1992), pp. 1161-1172.
Cyclopentenyl ethylamines active on CNS
Peana, Alessandra Tiziana;Pirisino, Gerolamo Antonio;Moretti, Mario Domenico Luigi;Satta, Margherita;Mulè, Antonio Calogero;
1992-01-01
Abstract
Two new cyclopentenylethylamines were prepared and were submitted to a pharmacological screening together with some others previously described and now reprepared. All compounds exhibited different degrees of depressive activity on CNS and good analgesic activity. Compound 5, bearing a phenyl group on the carbon atom to which the amino group is connected, appears rather interesting being the most active as analgesic and the least toxic. Compounds 2 and 3 are able to antagonize in a certain degree lethal doses of physostigmine and also, respectively, of pentylenetetrazole and strychnine.| File | Dimensione | Formato | |
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