Until 2020, extensively drug-resistant tuberculosis (XDR-TB) was defined as resistance to rifampicin and isoniazid (multidrug-resistant tuberculosis, MDR-TB), any fluoroquinolone (FQ) and any second-line injectable drug (SLID). In 2019 the World Health Organization issued new recommendations for managing patients with drug-resistant tuberculosis, substantially limiting the role of SLID in MDR-TB treatment and thus putting that XDR-TB definition into question.

Evidence-based Definition for Extensively Drug-resistant Tuberculosis / Roelens, M.; Migliori, G. B.; Rozanova, L.; Estill, J.; Campbell, J. R.; Cegielski, J. P.; Tiberi, S.; Palmero, D.; Fox, G. J.; Guglielmetti, L.; Sotgiu, G.; Brust, J. C. M.; Bang, D.; Lienhardt, C.; Lange, C.; Menzies, D.; Keiser, O.; Raviglione, M.. - In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. - ISSN 1073-449X. - (2021). [10.1164/rccm.202009-3527OC]

Evidence-based Definition for Extensively Drug-resistant Tuberculosis

Sotgiu G.;
2021-01-01

Abstract

Until 2020, extensively drug-resistant tuberculosis (XDR-TB) was defined as resistance to rifampicin and isoniazid (multidrug-resistant tuberculosis, MDR-TB), any fluoroquinolone (FQ) and any second-line injectable drug (SLID). In 2019 the World Health Organization issued new recommendations for managing patients with drug-resistant tuberculosis, substantially limiting the role of SLID in MDR-TB treatment and thus putting that XDR-TB definition into question.
2021
Evidence-based Definition for Extensively Drug-resistant Tuberculosis / Roelens, M.; Migliori, G. B.; Rozanova, L.; Estill, J.; Campbell, J. R.; Cegielski, J. P.; Tiberi, S.; Palmero, D.; Fox, G. J.; Guglielmetti, L.; Sotgiu, G.; Brust, J. C. M.; Bang, D.; Lienhardt, C.; Lange, C.; Menzies, D.; Keiser, O.; Raviglione, M.. - In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. - ISSN 1073-449X. - (2021). [10.1164/rccm.202009-3527OC]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/247139
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