A heteroleptic [Ru(terpy)(2)](2+) (terpy = 2,2 ':6 ',2 ''-terpyridine) complex was electrochemically polymerized to give the corresponding metal-containing conducting polymer on gold and glassy carbon electrodes. The polymerization of the Ru(II) complex was allowed by a terthiophene functionalization on one of the two terpy coordinating fragments, whereas the presence of -COOH substituents on the second terpy ligand enabled the film to immobilize a tyrosinase enzyme by cross-linking with glutaraldehyde. Then, the Ru(terpy) conducting polymer worked as a transducer as well as an immobilizing agent in the design of amperometric biosensors for the determination of epinephrine. The electrochemical behavior of enzymatic sensors containing Ru(terpy)-based conducting polymers was investigated by differential pulse voltammetry and chronoamperometry. Analytical performances and kinetic parameters were calculated, suggesting a potential application of the reported biosensors in the determination of epinephrine in pharmaceutical products.

Ru(terpy)-Based Conducting Polymer in Electrochemical Biosensing of Epinephrine / Meloni, Francesca; Pilo, Maria I.; Sanna, Gavino; Spano, Nadia; Zucca, Antonio. - In: APPLIED SCIENCES. - ISSN 2076-3417. - 11:5(2021), p. 2065. [10.3390/app11052065]

Ru(terpy)-Based Conducting Polymer in Electrochemical Biosensing of Epinephrine

Pilo, Maria I.
;
Sanna, Gavino;Spano, Nadia;Zucca, Antonio
2021

Abstract

A heteroleptic [Ru(terpy)(2)](2+) (terpy = 2,2 ':6 ',2 ''-terpyridine) complex was electrochemically polymerized to give the corresponding metal-containing conducting polymer on gold and glassy carbon electrodes. The polymerization of the Ru(II) complex was allowed by a terthiophene functionalization on one of the two terpy coordinating fragments, whereas the presence of -COOH substituents on the second terpy ligand enabled the film to immobilize a tyrosinase enzyme by cross-linking with glutaraldehyde. Then, the Ru(terpy) conducting polymer worked as a transducer as well as an immobilizing agent in the design of amperometric biosensors for the determination of epinephrine. The electrochemical behavior of enzymatic sensors containing Ru(terpy)-based conducting polymers was investigated by differential pulse voltammetry and chronoamperometry. Analytical performances and kinetic parameters were calculated, suggesting a potential application of the reported biosensors in the determination of epinephrine in pharmaceutical products.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/246555
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