Mycobacterium avium subsp. paratuberculosis (MAP), the causative agent of Johne's disease in ruminants, has been linked as a possible risk factor for human multiple sclerosis. In the current study we investigated the adjuvant effect of MAP on experimental autoimmune encephalomyelitis (EAE). Groups of C57BL/6 mice were actively immunized with myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide emulsified in incomplete Freund's adjuvant modified containing heat-killed MAP (MIFA). MOG-MIFA immunized mice showed an early disease onset and more severe clinical scores in comparison with MOG-CFA immunized mice, demonstrating for the first time the adjuvant effect of MAP on EAE development.

Adjuvant and antigenic properties of Mycobacterium avium subsp. paratuberculosis on experimental autoimmune encephalomyelitis / Cossu, D.; Yokoyama, K.; Sakanishi, T.; Momotani, E.; Hattori, N.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 330:(2019), pp. 174-177. [10.1016/j.jneuroim.2019.01.013]

Adjuvant and antigenic properties of Mycobacterium avium subsp. paratuberculosis on experimental autoimmune encephalomyelitis

Cossu D.;
2019-01-01

Abstract

Mycobacterium avium subsp. paratuberculosis (MAP), the causative agent of Johne's disease in ruminants, has been linked as a possible risk factor for human multiple sclerosis. In the current study we investigated the adjuvant effect of MAP on experimental autoimmune encephalomyelitis (EAE). Groups of C57BL/6 mice were actively immunized with myelin oligodendrocyte glycoprotein (MOG) 35–55 peptide emulsified in incomplete Freund's adjuvant modified containing heat-killed MAP (MIFA). MOG-MIFA immunized mice showed an early disease onset and more severe clinical scores in comparison with MOG-CFA immunized mice, demonstrating for the first time the adjuvant effect of MAP on EAE development.
2019
Adjuvant and antigenic properties of Mycobacterium avium subsp. paratuberculosis on experimental autoimmune encephalomyelitis / Cossu, D.; Yokoyama, K.; Sakanishi, T.; Momotani, E.; Hattori, N.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 330:(2019), pp. 174-177. [10.1016/j.jneuroim.2019.01.013]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/246058
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