The occurrence of multiple primary melanomas(MPM) is quite rare with an estimated incidence ranging from 0.2% to 8.6%(Buljan M et al.2010). However, the risk of developing a primary melanoma is increased in patients with a history of a previous melanoma compared with the general population (De Giorgi et al.,2012). Between 6 and 14% of MPM cases occur in individuals with a family history of disease (Ang CG et al.1998), suggesting a genetic component in the pathogenesis of MPM. Germline mutations in the CDKN2A gene have been widely reported as the most common cause of inherited susceptibility to melanoma (Palmieri G et al., 2009). In the literature,CDKN2A germline mutations have been identified in less than 2% of single primary melanoma cases, 8 to 12% of sporadic MPM cases and 47% of MPM patients with familial melanoma (De Giorgi V et al.,2014;Puig S et al.,2005). This article is protected by copyright
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Titolo: | Epidemiological features and prognostic parameters of multiple primary melanomas in CDKN2A-mutations patients |
Autori: | PALMIERI, Giuseppe [Investigation] |
Data di pubblicazione: | 2015 |
Rivista: | |
Handle: | http://hdl.handle.net/11388/245344 |
Appare nelle tipologie: | 1.1 Articolo in rivista |