The occurrence of multiple primary melanomas(MPM) is quite rare with an estimated incidence ranging from 0.2% to 8.6%(Buljan M et al.2010). However, the risk of developing a primary melanoma is increased in patients with a history of a previous melanoma compared with the general population (De Giorgi et al.,2012). Between 6 and 14% of MPM cases occur in individuals with a family history of disease (Ang CG et al.1998), suggesting a genetic component in the pathogenesis of MPM. Germline mutations in the CDKN2A gene have been widely reported as the most common cause of inherited susceptibility to melanoma (Palmieri G et al., 2009). In the literature,CDKN2A germline mutations have been identified in less than 2% of single primary melanoma cases, 8 to 12% of sporadic MPM cases and 47% of MPM patients with familial melanoma (De Giorgi V et al.,2014;Puig S et al.,2005). This article is protected by copyright

Epidemiological features and prognostic parameters of multiple primary melanomas in CDKN2A-mutations patients / De Giorgi, V; Savarese, I; D'Errico, A; Gori, A; Papi, F; Colombino, M; Sini, Mc; Grazzini, M; Stanganelli, I; Rossari, S; Covarelli, P; Massi, D; Palmieri, G. - In: PIGMENT CELL & MELANOMA RESEARCH. - ISSN 1755-148X. - 108:djv435(2015). [10.1111/pcmr.12403]

Epidemiological features and prognostic parameters of multiple primary melanomas in CDKN2A-mutations patients

Palmieri G
Investigation
2015

Abstract

The occurrence of multiple primary melanomas(MPM) is quite rare with an estimated incidence ranging from 0.2% to 8.6%(Buljan M et al.2010). However, the risk of developing a primary melanoma is increased in patients with a history of a previous melanoma compared with the general population (De Giorgi et al.,2012). Between 6 and 14% of MPM cases occur in individuals with a family history of disease (Ang CG et al.1998), suggesting a genetic component in the pathogenesis of MPM. Germline mutations in the CDKN2A gene have been widely reported as the most common cause of inherited susceptibility to melanoma (Palmieri G et al., 2009). In the literature,CDKN2A germline mutations have been identified in less than 2% of single primary melanoma cases, 8 to 12% of sporadic MPM cases and 47% of MPM patients with familial melanoma (De Giorgi V et al.,2014;Puig S et al.,2005). This article is protected by copyright
Epidemiological features and prognostic parameters of multiple primary melanomas in CDKN2A-mutations patients / De Giorgi, V; Savarese, I; D'Errico, A; Gori, A; Papi, F; Colombino, M; Sini, Mc; Grazzini, M; Stanganelli, I; Rossari, S; Covarelli, P; Massi, D; Palmieri, G. - In: PIGMENT CELL & MELANOMA RESEARCH. - ISSN 1755-148X. - 108:djv435(2015). [10.1111/pcmr.12403]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/245344
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact