Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV

Giuseppina, Sanna; Silvia, Madeddu; Gabriele, Serreli; Hoai Thi Nguyen,; Nhan Trong Le,; Usai, Donatella; Carta, Antonio; Piero, Cappuccinelli; Stefania Zanetti &amp;,; Matthew Gavino Donadu,

doi:10.1080/14786419.2020.1824228

In the prevention of epidemic and pandemic emerging and neglected viral infections, natural products are an important source of lead compounds. Hornstedtia bella Skornickis is a rhizomatous herb growing in the forest of central Vietnam. Hornstedtia bella essential oil (Hb EO) was recently characterised by our group as endowed of antimicrobial activity against Staphylococcus aureus Methicillin-Resistant strains. Here, we describe for the first time the evaluation of Hb EO against a spectrum of viruses responsible for important human diseases. Hb EO resulted active against Vaccinia virus (VV) (EC50 values 80 lg/mL), closely related to variola virus, causative agent of smallpox. Hb EO was able to strongly reduce the viral VV titer in cell-based assay at not cytotoxic concentration and its potential mode of action was characterised by virucidal activity evaluation followed by time-of-addition assay. Furthermore, Hb EO antiviral activity was implemented in a combination study with the mycophenolic acid.

Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV / Sanna, Giuseppina; Madeddu, Silvia; Serreli, Gabriele; Thi Nguyen, Hoai; Trong Le, Nhan; Usai, Donatella; Carta, Antonio; Cappuccinelli, Piero; Zanetti &, Stefania; Gavino Donadu, Matthew. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - (2020), pp. 1-7. [10.1080/14786419.2020.1824228]

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Titolo:	Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV
Autori:	Giuseppina Sanna (Corresponding) Silvia Madeddu Gabriele Serreli Hoai Thi Nguyen Nhan Trong Le [Membro del Collaboration Group] USAI, Donatella [Membro del Collaboration Group] CARTA, Antonio [Membro del Collaboration Group] Piero Cappuccinelli Stefania Zanetti & Matthew Gavino Donadu (Corresponding) mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2020
Rivista:	NATURAL PRODUCT RESEARCH
Citazione:	Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV / Sanna, Giuseppina; Madeddu, Silvia; Serreli, Gabriele; Thi Nguyen, Hoai; Trong Le, Nhan; Usai, Donatella; Carta, Antonio; Cappuccinelli, Piero; Zanetti &, Stefania; Gavino Donadu, Matthew. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - (2020), pp. 1-7. [10.1080/14786419.2020.1824228]
Handle:	http://hdl.handle.net/11388/241881
Appare nelle tipologie:	1.1 Articolo in rivista

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