In the prevention of epidemic and pandemic emerging and neglected viral infections, natural products are an important source of lead compounds. Hornstedtia bella Skornickis is a rhizomatous herb growing in the forest of central Vietnam. Hornstedtia bella essential oil (Hb EO) was recently characterised by our group as endowed of antimicrobial activity against Staphylococcus aureus Methicillin-Resistant strains. Here, we describe for the first time the evaluation of Hb EO against a spectrum of viruses responsible for important human diseases. Hb EO resulted active against Vaccinia virus (VV) (EC50 values 80 lg/mL), closely related to variola virus, causative agent of smallpox. Hb EO was able to strongly reduce the viral VV titer in cell-based assay at not cytotoxic concentration and its potential mode of action was characterised by virucidal activity evaluation followed by time-of-addition assay. Furthermore, Hb EO antiviral activity was implemented in a combination study with the mycophenolic acid.

Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV / Sanna, Giuseppina; Madeddu, Silvia; Serreli, Gabriele; Thi Nguyen, Hoai; Trong Le, Nhan; Usai, Donatella; Carta, Antonio; Cappuccinelli, Piero; Zanetti &, Stefania; Gavino Donadu, Matthew. - In: NATURAL PRODUCT RESEARCH. - ISSN 1478-6419. - (2020), pp. 1-7. [10.1080/14786419.2020.1824228]

Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV

Donatella Usai
Membro del Collaboration Group
;
Antonio Carta
Membro del Collaboration Group
;
2020

Abstract

In the prevention of epidemic and pandemic emerging and neglected viral infections, natural products are an important source of lead compounds. Hornstedtia bella Skornickis is a rhizomatous herb growing in the forest of central Vietnam. Hornstedtia bella essential oil (Hb EO) was recently characterised by our group as endowed of antimicrobial activity against Staphylococcus aureus Methicillin-Resistant strains. Here, we describe for the first time the evaluation of Hb EO against a spectrum of viruses responsible for important human diseases. Hb EO resulted active against Vaccinia virus (VV) (EC50 values 80 lg/mL), closely related to variola virus, causative agent of smallpox. Hb EO was able to strongly reduce the viral VV titer in cell-based assay at not cytotoxic concentration and its potential mode of action was characterised by virucidal activity evaluation followed by time-of-addition assay. Furthermore, Hb EO antiviral activity was implemented in a combination study with the mycophenolic acid.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/241881
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