Abstract: Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and about 20% is metastatic at diagnosis and untreatable. Increasing evidence suggests that the heterogeneous nature of CRC is related to colorectal cancer stem cells (CCSCs), a small cells population with stemness behaviors and responsible for tumor progression, recurrence, and therapy resistance. Growing knowledge of stem cells (SCs) biology has rapidly improved uncovering the molecular mechanisms and possible crosstalk/feedback loops between signaling pathways that directly influence intestinal homeostasis and tumorigenesis. The generation of CCSCs is probably connected to genetic changes in members of signaling pathways, which control self-renewal and pluripotency in SCs and then establish function and phenotype of CCSCs. Particularly, various deregulated CCSC-related miRNAs have been reported to modulate stemness features, controlling CCSCs functions such as regulation of cell cycle genes expression, epithelial-mesenchymal transition, metastasization, and drug-resistance mechanisms. Primarily, CCSC-related miRNAs work by regulating mainly signal pathways known to be involved in CCSCs biology. This review intends to summarize the epigenetic findings linked to miRNAome in the maintenance and regulation of CCSCs, including their relationships with different signaling pathways, which should help to identify specific diagnostic, prognostic, and predictive biomarkers for CRC, but also develop innovative CCSCs-targeted therapies.

Portrait of Cancer Stem Cells on Colorectal Cancer: Molecular Biomarkers, Signaling Pathways and miRNAome / Angius, Andrea; Scanu, Antonio Mario; Arru, Caterina; Muroni, Maria Rosaria; Rallo, Vincenzo; Deiana, Giulia; Ninniri, Maria Chiara; Carru, Ciriaco; Porcu, Alberto; Pira, Giovanna; Uva, Paolo; Paolo, Cossu-Rocca; DE MIGLIO, Maria Rosaria. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 22:1603(2021), pp. 1-35. [10.3390/ijms22041603]

Portrait of Cancer Stem Cells on Colorectal Cancer: Molecular Biomarkers, Signaling Pathways and miRNAome

Andrea Angius
Membro del Collaboration Group
;
Antonio Mario Scanu
Membro del Collaboration Group
;
Maria Rosaria Muroni
Membro del Collaboration Group
;
Giulia Deiana
Membro del Collaboration Group
;
Maria Chiara Ninniri
Membro del Collaboration Group
;
Ciriaco Carru
Membro del Collaboration Group
;
Alberto Porcu
Membro del Collaboration Group
;
Paolo Cossu-Rocca
Membro del Collaboration Group
;
Maria Rosaria De Miglio
Membro del Collaboration Group
2021-01-01

Abstract

Abstract: Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and about 20% is metastatic at diagnosis and untreatable. Increasing evidence suggests that the heterogeneous nature of CRC is related to colorectal cancer stem cells (CCSCs), a small cells population with stemness behaviors and responsible for tumor progression, recurrence, and therapy resistance. Growing knowledge of stem cells (SCs) biology has rapidly improved uncovering the molecular mechanisms and possible crosstalk/feedback loops between signaling pathways that directly influence intestinal homeostasis and tumorigenesis. The generation of CCSCs is probably connected to genetic changes in members of signaling pathways, which control self-renewal and pluripotency in SCs and then establish function and phenotype of CCSCs. Particularly, various deregulated CCSC-related miRNAs have been reported to modulate stemness features, controlling CCSCs functions such as regulation of cell cycle genes expression, epithelial-mesenchymal transition, metastasization, and drug-resistance mechanisms. Primarily, CCSC-related miRNAs work by regulating mainly signal pathways known to be involved in CCSCs biology. This review intends to summarize the epigenetic findings linked to miRNAome in the maintenance and regulation of CCSCs, including their relationships with different signaling pathways, which should help to identify specific diagnostic, prognostic, and predictive biomarkers for CRC, but also develop innovative CCSCs-targeted therapies.
Portrait of Cancer Stem Cells on Colorectal Cancer: Molecular Biomarkers, Signaling Pathways and miRNAome / Angius, Andrea; Scanu, Antonio Mario; Arru, Caterina; Muroni, Maria Rosaria; Rallo, Vincenzo; Deiana, Giulia; Ninniri, Maria Chiara; Carru, Ciriaco; Porcu, Alberto; Pira, Giovanna; Uva, Paolo; Paolo, Cossu-Rocca; DE MIGLIO, Maria Rosaria. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 22:1603(2021), pp. 1-35. [10.3390/ijms22041603]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/241623
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