The survival rate for patients with metastatic hepatoblastoma (HB) is steadily increased in the last thirty years from 27% to 79%. These achievements result from accurate risk stratification and effective chemotherapy and surgical care. However, patients with poor prognosis require more effective therapies. Recent years have witnessed new insights on the biology of HB, setting the stage for molecular classification and new targets of therapy. We review here the molecular pathology of HB, focusing on the driver genes involved in the process of oncogenesis and the identification of novel targets. We also address the role of in vivo models in elucidating the mechanisms of development of this disease and the pre-clinical phase of new treatment modalities.

Hepatoblastoma: Current knowledge and promises from preclinical studies / Calvisi, D. F.; Solinas, A.. - In: TRANSLATIONAL GASTROINTESTINAL CANCER. - ISSN 2224-476X. - 5:(2020), pp. 42-42. [10.21037/tgh.2019.12.03]

Hepatoblastoma: Current knowledge and promises from preclinical studies

Calvisi D. F.
;
Solinas A.
2020-01-01

Abstract

The survival rate for patients with metastatic hepatoblastoma (HB) is steadily increased in the last thirty years from 27% to 79%. These achievements result from accurate risk stratification and effective chemotherapy and surgical care. However, patients with poor prognosis require more effective therapies. Recent years have witnessed new insights on the biology of HB, setting the stage for molecular classification and new targets of therapy. We review here the molecular pathology of HB, focusing on the driver genes involved in the process of oncogenesis and the identification of novel targets. We also address the role of in vivo models in elucidating the mechanisms of development of this disease and the pre-clinical phase of new treatment modalities.
2020
Hepatoblastoma: Current knowledge and promises from preclinical studies / Calvisi, D. F.; Solinas, A.. - In: TRANSLATIONAL GASTROINTESTINAL CANCER. - ISSN 2224-476X. - 5:(2020), pp. 42-42. [10.21037/tgh.2019.12.03]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/240489
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