Coronavirus disease 2019 (COVID-19) is a recently described infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since late 2019, COVID-19 has rapidly spread in virtually all countries, imposing the adoption of significant lockdown and social distancing measures. The activation of the coagulation cascade is a common feature of disseminated intravascular coagulation and adverse clinical outcomes in COVID-19 patients. In this study, we conducted a meta-analysis aiming to investigate differences in serum D-dimer concentrations in patients with and without severe COVID-19 disease. An electronic search in Medline (PubMed), Scopus and Web of Science was performed with no language restrictions, and 13 articles were reporting on 1,807 patients (585, 32.4% with severe disease) were finally identified and included in the meta-analysis. The pooled results of all studies revealed that the D-dimer concentrations were significantly higher in patients with more severe COVID-19 (SMD: 0.91 mg/L; 95% CI, 0.75 to 1.07 mg/L,p< 0.0001). The heterogeneity was moderate (I-2= 46.5%;p= 0.033). Sensitivity analysis showed that the effect size was not modified when any single study was in turn removed (effect size range, 0.87 mg/L to 0.93 mg/L). The Begg's (p= 0.76) and Egger's tests (p= 0.38) showed no publication bias. In conclusion, our systematic review and meta-analysis showed that serum D-dimer concentrations in patients with severe COVID-19 are significantly higher when compared to those with non-severe forms.

D-Dimer Concentrations and COVID-19 Severity: A Systematic Review and Meta-Analysis / Paliogiannis, Panagiotis; Mangoni, Arduino Aleksander; Dettori, Paola; Nasrallah, Gheyath K; Pintus, Gianfranco; Zinellu, Angelo. - In: FRONTIERS IN PUBLIC HEALTH. - ISSN 2296-2565. - 8(2020), p. 432. [10.3389/fpubh.2020.00432]

D-Dimer Concentrations and COVID-19 Severity: A Systematic Review and Meta-Analysis

Paliogiannis, Panagiotis;Mangoni, Arduino Aleksander;Dettori, Paola;Pintus, Gianfranco
;
Zinellu, Angelo
2020

Abstract

Coronavirus disease 2019 (COVID-19) is a recently described infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since late 2019, COVID-19 has rapidly spread in virtually all countries, imposing the adoption of significant lockdown and social distancing measures. The activation of the coagulation cascade is a common feature of disseminated intravascular coagulation and adverse clinical outcomes in COVID-19 patients. In this study, we conducted a meta-analysis aiming to investigate differences in serum D-dimer concentrations in patients with and without severe COVID-19 disease. An electronic search in Medline (PubMed), Scopus and Web of Science was performed with no language restrictions, and 13 articles were reporting on 1,807 patients (585, 32.4% with severe disease) were finally identified and included in the meta-analysis. The pooled results of all studies revealed that the D-dimer concentrations were significantly higher in patients with more severe COVID-19 (SMD: 0.91 mg/L; 95% CI, 0.75 to 1.07 mg/L,p< 0.0001). The heterogeneity was moderate (I-2= 46.5%;p= 0.033). Sensitivity analysis showed that the effect size was not modified when any single study was in turn removed (effect size range, 0.87 mg/L to 0.93 mg/L). The Begg's (p= 0.76) and Egger's tests (p= 0.38) showed no publication bias. In conclusion, our systematic review and meta-analysis showed that serum D-dimer concentrations in patients with severe COVID-19 are significantly higher when compared to those with non-severe forms.
D-Dimer Concentrations and COVID-19 Severity: A Systematic Review and Meta-Analysis / Paliogiannis, Panagiotis; Mangoni, Arduino Aleksander; Dettori, Paola; Nasrallah, Gheyath K; Pintus, Gianfranco; Zinellu, Angelo. - In: FRONTIERS IN PUBLIC HEALTH. - ISSN 2296-2565. - 8(2020), p. 432. [10.3389/fpubh.2020.00432]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/236063
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 48
  • ???jsp.display-item.citation.isi??? 42
social impact