Background: Given the increasing request for natural pharmacological molecules, this study assessed the antimicrobial capacity of Pistacialentiscus L. essential oil (PLL-EO) obtained from the leaves of wild plants growing in North Sardinia (Italy) toward a wide range of periodontal bacteria and Candida, including laboratory and clinical isolates sp., together with its antiinflammatory activity and safety. Methods: PLL-EO was screened by gas chromatography/mass spectrometry. The minimal inhibitory concentration (MIC) was determined. The anti-inflammatory activity was measured by cyclooxygenase (COX-1/2) and lipoxygenase (LOX) inhibition, while the antioxidant capacity was determined electro-chemically and by the MTT assay. The WST-1 assay was used to ascertain cytotoxicity toward four lines of oral cells. Results: According to the concentrations of terpens, PLL-EO is a pharmacologically-active phytocomplex. MICs against periodontal bacteria ranged between 3.13 and 12.5 µg/ml, while against Candida sp. they were between 6.25 and 12.5 µg/mL. Oxidation by COX-1/2 and LOX was inhibited by 80% and 20% µg/mL of the oil, respectively. Antioxidant activity seemed negligible, and no cytotoxicity arose. Conclusions: PLL-EO exhibits a broad-spectrum activity against periodontal bacteria and Candida,.

The pharmaceutical ability of Pistacia lentiscus L. Leaves essential oil against periodontal bacteria and Candida sp. and its anti-inflammatory potential / Milia, E.; Usai, M.; Szotakova, B.; Elstnerova, M.; Kralova, V.; D'hallewin, G.; Spissu, Y.; Barberis, A.; Marchetti, M.; Bortone, A.; Campanella, V.; Mastandrea, G.; Langhansova, L.; Eick, S.. - In: ANTIBIOTICS. - ISSN 2079-6382. - 9:6(2020), p. 281. [10.3390/antibiotics9060281]

The pharmaceutical ability of Pistacia lentiscus L. Leaves essential oil against periodontal bacteria and Candida sp. and its anti-inflammatory potential

Milia E.
Writing – Review & Editing
;
Usai M.
Investigation
;
D'hallewin G.
Methodology
;
Spissu Y.
Investigation
;
Bortone A.
Investigation
;
Mastandrea G.
Data Curation
;
2020

Abstract

Background: Given the increasing request for natural pharmacological molecules, this study assessed the antimicrobial capacity of Pistacialentiscus L. essential oil (PLL-EO) obtained from the leaves of wild plants growing in North Sardinia (Italy) toward a wide range of periodontal bacteria and Candida, including laboratory and clinical isolates sp., together with its antiinflammatory activity and safety. Methods: PLL-EO was screened by gas chromatography/mass spectrometry. The minimal inhibitory concentration (MIC) was determined. The anti-inflammatory activity was measured by cyclooxygenase (COX-1/2) and lipoxygenase (LOX) inhibition, while the antioxidant capacity was determined electro-chemically and by the MTT assay. The WST-1 assay was used to ascertain cytotoxicity toward four lines of oral cells. Results: According to the concentrations of terpens, PLL-EO is a pharmacologically-active phytocomplex. MICs against periodontal bacteria ranged between 3.13 and 12.5 µg/ml, while against Candida sp. they were between 6.25 and 12.5 µg/mL. Oxidation by COX-1/2 and LOX was inhibited by 80% and 20% µg/mL of the oil, respectively. Antioxidant activity seemed negligible, and no cytotoxicity arose. Conclusions: PLL-EO exhibits a broad-spectrum activity against periodontal bacteria and Candida,.
The pharmaceutical ability of Pistacia lentiscus L. Leaves essential oil against periodontal bacteria and Candida sp. and its anti-inflammatory potential / Milia, E.; Usai, M.; Szotakova, B.; Elstnerova, M.; Kralova, V.; D'hallewin, G.; Spissu, Y.; Barberis, A.; Marchetti, M.; Bortone, A.; Campanella, V.; Mastandrea, G.; Langhansova, L.; Eick, S.. - In: ANTIBIOTICS. - ISSN 2079-6382. - 9:6(2020), p. 281. [10.3390/antibiotics9060281]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/235200
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