CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishThe present paper shows demographic, clinical, anamnestic, cognitive, and functional data as well as biochemical, genetic, and epigenetic parameters of two exceptional siblings: Diega (supercentenarian) and Filippa (semi-supercentenarian) Cammalleri. The purpose of this study is to provide new insights into the extreme phenotypes represented by semi and supercentenarians. Different studies have been published on supercentenarians, but to best of our knowledge, this is the only concerning two siblings and well detailed from a phenotypic point of view. Our findings agree with the suggestion that supercentenarians have an increasing relative resistance to age-related diseases, approximating the limits of the functional human reserve to address successfully the acute causes of death. More interestingly, our data agree with, and extend, the suggestion that inflammation and oxidative stress predict centenarian mortality.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
| Titolo: | The Phenotypic Characterization of the Cammalleri Sisters, an Example of Exceptional Longevity |
| Autori: | |
| Data di pubblicazione: | 2020 |
| Rivista: | |
| Abstract: | The present paper shows demographic, clinical, anamnestic, cognitive, and functional data as well as biochemical, genetic, and epigenetic parameters of two exceptional siblings: Diega (supercentenarian) and Filippa (semi-supercentenarian) Cammalleri. The purpose of this study is to provide new insights into the extreme phenotypes represented by semi and supercentenarians. Different studies have been published on supercentenarians, but to best of our knowledge, this is the only concerning two siblings and well detailed from a phenotypic point of view. Our findings agree with the suggestion that supercentenarians have an increasing relative resistance to age-related diseases, approximating the limits of the functional human reserve to address successfully the acute causes of death. More interestingly, our data agree with, and extend, the suggestion that inflammation and oxidative stress predict centenarian mortality. |
| Handle: | http://hdl.handle.net/11388/233208 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
Copyright © 2020