Integration of intracellular signaling: Biological analogues of wires, processors and memories organized by a centrosome 3D reference system

Barvitenko, N.; Lawen, A.; Aslam, M.; Pantaleo, A.; Saldanha, C.; Skverchinskaya, E.; Regolini, M.; Tuszynski, J. A.

doi:10.1016/j.biosystems.2018.08.007

Background: Myriads of signaling pathways in a single cell function to achieve the highest spatio-temporal integration. Data are accumulating on the role of electromechanical soliton-like waves in signal transduction processes. Theoretical studies strongly suggest feasibility of both classical and quantum computing involving microtubules. Aim: A theoretical study of the role of the complex composed of the plasma membrane and the microtubule-based cytoskeleton as a system that transmits, stores and processes information. Methods: Theoretical analysis presented here refers to (i) the Penrose–Hameroff theory of consciousness (Orchestrated Objective Reduction; Orch OR), (ii) the description of the centrosome as a reference system for construction of the 3D map of the cell proposed by Regolini, (iii) the Heimburg–Jackson model of the nerve pulse propagation along axons’ lipid bilayer as soliton-like electro-mechanical waves. Results and conclusion: The ideas presented in this paper provide a qualitative model for the decision-making processes in a living cell undergoing a differentiation process. Outlook: This paper paves the way for the real-time live-cell observation of information processing by microtubule-based cytoskeleton and cell fate decision making.

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Titolo:	Integration of intracellular signaling: Biological analogues of wires, processors and memories organized by a centrosome 3D reference system
Autori:	Barvitenko N. Lawen A. Aslam M. PANTALEO, Antonella Saldanha C. Skverchinskaya E. Regolini M. Tuszynski J. A. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2018
Rivista:	BIOSYSTEMS
Handle:	http://hdl.handle.net/11388/227549
Appare nelle tipologie:	1.1 Articolo in rivista

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http://hdl.handle.net/11388/227549

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