Depopulation is a problemfelt inmany regions of the EuropeanUnion,mainly affecting inland and rural areas. In many cases, these areas are characterized by economic, social, and infrastructural marginalization. Their rehabilitation is desirable in view of a better balance of social and infrastructural management. This said, there are no proven solutions for depopulation that can be applied to all territories in the same way. On the contrary, if we examine progress in the fields of ITC and digitization, we can gather interesting suggestions on how to deal with this issue. This essay intends to analyze these aspects and to examine ways to strengthen, through programs and instruments of the sharing economy, the competitiveness and potential attraction of geographical areas considered marginal and that risk demographic collapse.