Solvents represent one of the major contributions to the environmental impact of fine‐chemical synthesis. As a result, the use of environmentally friendly solvents in widely employed reactions is a challenge of vast real interest in contemporary organic chemistry. Within this Review, a great variety of examples showing how cyclopentyl methyl ether has been established as particularly useful for this purpose are reported. Indeed, its low toxicity, high boiling point, low melting point, hydrophobicity, chemical stability towards a wide range of conditions, exceptional stability towards the abstraction of hydrogen atoms, relatively low latent heat of vaporization, and the ease with which it can be recovered and recycled enable its successful employment as a solvent in a wide range of synthetic applications, including organometallic chemistry, catalysis, biphasic reactions, oxidations, and radical reactions.

Cyclopentyl methyl ether: an elective eco-friendly ethereal solvent in classical and modern organic chemistry / Azzena, Ugo Gavino; Carraro, Massimo; Pisano, Luisa; Monticelli, Serena; Bartolotta, Roberta; Pace, Vittorio. - In: CHEMSUSCHEM. - ISSN 1864-564X. - 12:1(2019), pp. 40-70. [10.1002/cssc.201801768]

Cyclopentyl methyl ether: an elective eco-friendly ethereal solvent in classical and modern organic chemistry

Ugo, Azzena
Membro del Collaboration Group
;
Massimo, Carraro
Membro del Collaboration Group
;
Luisa, Pisano
Membro del Collaboration Group
;
2019-01-01

Abstract

Solvents represent one of the major contributions to the environmental impact of fine‐chemical synthesis. As a result, the use of environmentally friendly solvents in widely employed reactions is a challenge of vast real interest in contemporary organic chemistry. Within this Review, a great variety of examples showing how cyclopentyl methyl ether has been established as particularly useful for this purpose are reported. Indeed, its low toxicity, high boiling point, low melting point, hydrophobicity, chemical stability towards a wide range of conditions, exceptional stability towards the abstraction of hydrogen atoms, relatively low latent heat of vaporization, and the ease with which it can be recovered and recycled enable its successful employment as a solvent in a wide range of synthetic applications, including organometallic chemistry, catalysis, biphasic reactions, oxidations, and radical reactions.
2019
Cyclopentyl methyl ether: an elective eco-friendly ethereal solvent in classical and modern organic chemistry / Azzena, Ugo Gavino; Carraro, Massimo; Pisano, Luisa; Monticelli, Serena; Bartolotta, Roberta; Pace, Vittorio. - In: CHEMSUSCHEM. - ISSN 1864-564X. - 12:1(2019), pp. 40-70. [10.1002/cssc.201801768]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/219385
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