Introduction: Essential oils have been used since ancient times and are known for their anti-inflammatory, anti-depressive, antiseptic, antifungal and antimicrobial properties. Methodology: in this study the antimicrobial activity of two essential oils from Melaleuca alternifolia and Thymus vulgaris–red thyme geraniol was tested against 16 multidrug-resistant P. aeruginosa strains from infected hip implants as well as the “in vitro” cytotoxic activity on normal human Wong-Kilbourne derivative (WKD) cells. Results: Thymus vulgaris–red thyme geraniol showed lower antimicrobial activity when compared to Melaleuca alternifolia. All tested oils were cytotoxic at concentrations lower than 0.12%. Conclusion: Increase in drug resistance and lack of new antibiotics may encourage the development of natural treatments together with higher concern on environmental issues and natural lifestyle.
In vitro activity of essential oils against pseudomonas aeruginosa isolated from infected hip implants / Amorese, Veronica; Donadu, Matthew Gavino; Usai, Donatella; Sanna, Angelino; Milia, Fabio; Pisanu, Francesco; Molicotti, Paola; Zanetti, Stefania; Doria, Carlo. - In: JOURNAL OF INFECTION IN DEVELOPING COUNTRIES. - ISSN 2036-6590. - 12:11(2018), pp. 996-1001. [10.3855/jidc.10988]
In vitro activity of essential oils against pseudomonas aeruginosa isolated from infected hip implants
Amorese, Veronica;Donadu, Matthew Gavino;Usai, Donatella;SANNA, Angelino;Pisanu, Francesco;Molicotti, Paola;Zanetti, Stefania;Doria, Carlo
2018-01-01
Abstract
Introduction: Essential oils have been used since ancient times and are known for their anti-inflammatory, anti-depressive, antiseptic, antifungal and antimicrobial properties. Methodology: in this study the antimicrobial activity of two essential oils from Melaleuca alternifolia and Thymus vulgaris–red thyme geraniol was tested against 16 multidrug-resistant P. aeruginosa strains from infected hip implants as well as the “in vitro” cytotoxic activity on normal human Wong-Kilbourne derivative (WKD) cells. Results: Thymus vulgaris–red thyme geraniol showed lower antimicrobial activity when compared to Melaleuca alternifolia. All tested oils were cytotoxic at concentrations lower than 0.12%. Conclusion: Increase in drug resistance and lack of new antibiotics may encourage the development of natural treatments together with higher concern on environmental issues and natural lifestyle.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
