Experimental evidence suggests that oxidative stress (OS) may increase the activity of arginine methylating enzymes that produce the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA). In addition, it is well documented that OS can significantly decrease the synthesis and/or activity of ADMA degrading enzymes, thus causing ADMA accumulation in biological fluids. Recent reports have focused on circulating methylated arginine concentrations in chronic obstructive pulmonary disease, a disease characterized by a significant increase in OS. This review discusses the results of these studies and the opportunities for further research in this area.
Systemic concentrations of asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD): state of the art / Zinellu, Angelo; Fois, Alessandro G.; Mangoni, Arduino A.; Paliogiannis, Panagiotis; Sotgiu, Elisabetta; Zinellu, Elisabetta; Marras, Viviana; Pirina, Pietro; Carru, Ciriaco. - In: AMINO ACIDS. - ISSN 0939-4451. - 50:9(2018), pp. 1169-1176. [10.1007/s00726-018-2606-7]
Systemic concentrations of asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD): state of the art
Zinellu, Angelo;Fois, Alessandro G.;Mangoni, Arduino A.;Paliogiannis, Panagiotis;Sotgiu, Elisabetta;Zinellu, Elisabetta;Marras, Viviana;Pirina, Pietro
;Carru, Ciriaco
2018-01-01
Abstract
Experimental evidence suggests that oxidative stress (OS) may increase the activity of arginine methylating enzymes that produce the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA). In addition, it is well documented that OS can significantly decrease the synthesis and/or activity of ADMA degrading enzymes, thus causing ADMA accumulation in biological fluids. Recent reports have focused on circulating methylated arginine concentrations in chronic obstructive pulmonary disease, a disease characterized by a significant increase in OS. This review discusses the results of these studies and the opportunities for further research in this area.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
