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Background: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. Methods: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. Results: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01–2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02–2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%. Conclusion: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.
An international perspective on hospitalized patients with viral community-acquired pneumonia
Radovanovic, Dejan;Sotgiu, Giovanni;Jankovic, Mateja;Mahesh, Padukudru Anand;Marcos, Pedro Jorge;Abdalla, Mohamed I.;Di Pasquale, Marta Francesca;Gramegna, Andrea;Terraneo, Silvia;Blasi, Francesco;Santus, Pierachille;Aliberti, Stefano;Reyes, Luis F.;Restrepo, Marcos I.;Aruj, Patricia Karina;Attorri, Silvia;Barimboim, Enrique;Caeiro, Juan Pablo;Garzón, María I.;Cambursano, Victor Hugo;Ceccato, Adrian;Chertcoff, Julio;Cordon Díaz, Ariel;de Vedia, Lautaro;Ganaha, Maria Cristina;Lambert, Sandra;Lopardo, Gustavo;Luna, Carlos M.;Malberti, Alessio Gerardo;Morcillo, Nora;Tartara, Silvina;Pensotti, Claudia;Pereyra, Betiana;Scapellato, Pablo Gustavo;Stagnaro, Juan Pablo;Shah, Sonali;Lötsch, Felix;Thalhammer, Florian;Anseeuw, Kurt;Francois, Camille A.;Van Braeckel, Eva;Vincent, Jean Louis;Djimon, Marcel Zannou;Aranha Nouér, Simone;Chipev, Peter;Encheva, Milena;Miteva, Darina;Petkova, Diana;Balkissou, Adamou Dodo;Pefura Yone, Eric Walter;Mbatchou Ngahane, Bertrand Hugo;Shen, Ning;Xu, Jin-fu;Bustamante Rico, Carlos Andres;Buitrago, Ricardo;Pereira Paternina, Fernando Jose;Kayembe Ntumba, Jean-Marie;Vladic-Carevic, Vesna;Jakopovic, Marko;Matkovic, Zinka;Mitrecic, Ivan;Bouchy Jacobsson, Marie-Laure;Bro Christensen, Anette;Heitmann Bødtger, Uffe Christian;Meyer, Christian Niels;Vestergaard Jensen, Andreas;El-Said Abd El-Wahhab, Ibrahim;Elsayed Morsy, Nesreen;Shafiek, Hanaa;Sobh, Eman;Abdulsemed, Kedir Abdella;Bertrand, Fabrice;Brun-Buisson, Christian;de Montmollin, Etienne;Fartoukh, Muriel;Messika, Jonathan;Tattevin, Pierre;Khoury, Abdo;Ebruke, Bernard;Dreher, Michael;Kolditz, Martin;Meisinger, Matthias;Pletz, Mathias W.;Hagel, Stefan;Rupp, Jan;Schaberg, Tom;Spielmanns, Marc;Creutz, Petra;Suttorp, Norton;Siaw-Lartey, Beatrice;Dimakou, Katerina;Papapetrou, Dimosthenis;Tsigou, Evdoxia;Ampazis, Dimitrios;Kaimakamis, Evangelos;Bhatia, Mohit;Dhar, Raja;D'Souza, George;Garg, Rajiv;Koul, Parvaiz A.;Jayaraj, B. S.;Narayan, Kiran Vishnu;Udnur, Hirennappa B.;Krishnamurthy, Shashi Bhaskara;Kant, Surya;Swarnakar, Rajesh;Salvi, Sundeep;Limaye, Sneha;Golshani, Keihan;Keatings, Vera M.;Martin-Loeches, Ignacio;Maor, Yasmin;Strahilevitz, Jacob;Battaglia, Salvatore;Carrabba, Maria;Ceriana, Piero;Confalonieri, Marco;d'Arminio Monforte, Antonella;Del Prato, Bruno;De Rosa, Marino;Fantini, Riccardo;Fiorentino, Giuseppe;Gammino, Maria Antonia;Menzella, Francesco;Milani, Giuseppe;Nava, Stefano;Palmiero, Gerardo;Petrino, Roberta;Gabrielli, Barbra;Rossi, Paolo;Sorino, Claudio;Steinhilber, Gundi;Zanforlin, Alessandro;Franzetti, Fabio;Carone, Mauro;Patella, Vincenzo;Scarlata, Simone;Comel, Andrea;Kurahashi, Kiyoyasu;Aoun Bacha, Zeina;Barajas Ugalde, Daniel;Ceballos Zuñiga, Omar;Villegas, José F.;Medenica, Milic;van de Garde, E. M. W.;Raj Mihsra, Deebya;Shrestha, Poojan;Ridgeon, Elliott;Ishola Awokola, Babatunde;Nwankwo, Ogonna N. O.;Olufunlola, Adefuye Bolanle;Olumide, Segaolu;Ukwaja, Kingsley N.;Irfan, Muhammad;Minarowski, Lukasz;Szymon, Skoczyński;Froes, Felipe;Leuschner, Pedro;Meireles, Mariana;Ferrão, Cláudia;Neves, João;Ravara, Sofia B.;Brocovschii, Victoria;Ion, Chesov;Rusu, Doina;Toma, Cristina;Chirita, Daniela;Dorobat, Carmen Mihaela;Birkun, Alexei;Kaluzhenina, Anna;Almotairi, Abdullah;Bukhary, Zakeya Abdulbaqi Ali;Edathodu, Jameela;Fathy, Amal;Mushira Abdulaziz Enani, Abdullah;Eltayeb Mohamed, Nazik;Ulhadi Memon, Jawed;Bella, Abdelhaleem;Bogdanović, Nada;Milenkovic, Branislava;Pesut, Dragica;Borderìas, Luis;Bordon Garcia, Noel Manuel;Cabello Alarcón, Hugo;Cilloniz, Catia;Torres, Antoni;Diaz-Brito, Vicens;Casas, Xavier;Encabo González, Alicia;Fernández-Almira, Maria Luisa;Gallego, Miguel;Gaspar-GarcÍa, Inmaculada;González Del Castillo, Juan;Javaloyes Victoria, Patricia;Laserna Martínez, Elena;Malo de Molina, Rosa;Menéndez, Rosario;Pando-Sandoval, Ana;Prat Aymerich, Cristina;Lacoma de la Torre, Alicia;García-Olivé, Ignasi;Rello, Jordi;Moyano, Silvia;Sanz, Francisco;Sibila, Oriol;Rodrigo-Troyano, Ana;Solé-Violán, Jordi;Uranga, Ane;van Boven, Job F. M.;Vendrell Torra, Ester;Pujol, Jordi Almirall;Feldman, Charles;Kee Yum, Ho;Fiogbe, Arnauld Attannon;Yangui, Ferdaous;Bilaceroglu, Semra;Dalar, Levent;Yilmaz, Ufuk;Bogomolov, Artemii;Elahi, Naheed;Dhasmana, Devesh J.;Feneley, Andrew;Hancock, Carole;Hill, Adam T.;Rudran, Banu;Ruiz-Buitrago, Silvia;Campbell, Marion;Whitaker, Paul;Youzguin, Alexander;Singanayagam, Anika;Allen, Karen S.;Brito, Veronica;Dietz, Jessica;Dysart, Claire E.;Kellie, Susan M.;Franco-Sadud, Ricardo A.;Meier, Garnet;Gaga, Mina;Holland, Thomas L.;Bergin, Stephen P.;Kheir, Fayez;Landmeier, Mark;Lois, Manuel;Nair, Girish B.;Patel, Hemali;Reyes, Katherine;Rodriguez-Cintron, William;Saito, Shigeki;Soni, Nilam J.;Noda, Julio;Hinojosa, Cecilia I.;Levine, Stephanie M.;Angel, Luis F.;Anzueto, Antonio;Scott Whitlow, K.;Hipskind, John;Sukhija, Kunal;Totten, Vicken;Wunderink, Richard G.;Shah, Ray D.;Mateyo, Kondwelani John;Carugati, Manuela;Morosi, Manuela;Monge, Elisa
2018-01-01
Abstract
Background: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. Methods: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. Results: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01–2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02–2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%. Conclusion: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/217482
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simulazione ASN
Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
La presente simulazione è stata realizzata sulla base delle specifiche raccolte sul tavolo ER del Focus Group IRIS coordinato dall’Università di Modena e Reggio Emilia e delle regole riportate nel DM 589/2018 e allegata Tabella A. Cineca, l’Università di Modena e Reggio Emilia e il Focus Group IRIS non si assumono alcuna responsabilità in merito all’uso che il diretto interessato o terzi faranno della simulazione. Si specifica inoltre che la simulazione contiene calcoli effettuati con dati e algoritmi di pubblico dominio e deve quindi essere considerata come un mero ausilio al calcolo svolgibile manualmente o con strumenti equivalenti.
