Background: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. Methods: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. Results: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01–2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02–2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%. Conclusion: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.

An international perspective on hospitalized patients with viral community-acquired pneumonia / Radovanovic, Dejan; Sotgiu, Giovanni; Jankovic, Mateja; Mahesh, Padukudru Anand; Marcos, Pedro Jorge; Abdalla, Mohamed I.; Di Pasquale, Marta Francesca; Gramegna, Andrea; Terraneo, Silvia; Blasi, Francesco; Santus, Pierachille; Aliberti, Stefano; Reyes, Luis F.; Restrepo, Marcos I.; Aruj, Patricia Karina; Attorri, Silvia; Barimboim, Enrique; Caeiro, Juan Pablo; Garzón, María I.; Cambursano, Victor Hugo; Ceccato, Adrian; Chertcoff, Julio; Cordon Díaz, Ariel; de Vedia, Lautaro; Ganaha, Maria Cristina; Lambert, Sandra; Lopardo, Gustavo; Luna, Carlos M.; Malberti, Alessio Gerardo; Morcillo, Nora; Tartara, Silvina; Pensotti, Claudia; Pereyra, Betiana; Scapellato, Pablo Gustavo; Stagnaro, Juan Pablo; Shah, Sonali; Lötsch, Felix; Thalhammer, Florian; Anseeuw, Kurt; Francois, Camille A.; Van Braeckel, Eva; Vincent, Jean Louis; Djimon, Marcel Zannou; Aranha Nouér, Simone; Chipev, Peter; Encheva, Milena; Miteva, Darina; Petkova, Diana; Balkissou, Adamou Dodo; Pefura Yone, Eric Walter; Mbatchou Ngahane, Bertrand Hugo; Shen, Ning; Xu, Jin-fu; Bustamante Rico, Carlos Andres; Buitrago, Ricardo; Pereira Paternina, Fernando Jose; Kayembe Ntumba, Jean-Marie; Vladic-Carevic, Vesna; Jakopovic, Marko; Matkovic, Zinka; Mitrecic, Ivan; Bouchy Jacobsson, Marie-Laure; Bro Christensen, Anette; Heitmann Bødtger, Uffe Christian; Meyer, Christian Niels; Vestergaard Jensen, Andreas; El-Said Abd El-Wahhab, Ibrahim; Elsayed Morsy, Nesreen; Shafiek, Hanaa; Sobh, Eman; Abdulsemed, Kedir Abdella; Bertrand, Fabrice; Brun-Buisson, Christian; de Montmollin, Etienne; Fartoukh, Muriel; Messika, Jonathan; Tattevin, Pierre; Khoury, Abdo; Ebruke, Bernard; Dreher, Michael; Kolditz, Martin; Meisinger, Matthias; Pletz, Mathias W.; Hagel, Stefan; Rupp, Jan; Schaberg, Tom; Spielmanns, Marc; Creutz, Petra; Suttorp, Norton; Siaw-Lartey, Beatrice; Dimakou, Katerina; Papapetrou, Dimosthenis; Tsigou, Evdoxia; Ampazis, Dimitrios; Kaimakamis, Evangelos; Bhatia, Mohit; Dhar, Raja; D'Souza, George; Garg, Rajiv; Koul, Parvaiz A.; Jayaraj, B. S.; Narayan, Kiran Vishnu; Udnur, Hirennappa B.; Krishnamurthy, Shashi Bhaskara; Kant, Surya; Swarnakar, Rajesh; Salvi, Sundeep; Limaye, Sneha; Golshani, Keihan; Keatings, Vera M.; Martin-Loeches, Ignacio; Maor, Yasmin; Strahilevitz, Jacob; Battaglia, Salvatore; Carrabba, Maria; Ceriana, Piero; Confalonieri, Marco; d'Arminio Monforte, Antonella; Del Prato, Bruno; De Rosa, Marino; Fantini, Riccardo; Fiorentino, Giuseppe; Gammino, Maria Antonia; Menzella, Francesco; Milani, Giuseppe; Nava, Stefano; Palmiero, Gerardo; Petrino, Roberta; Gabrielli, Barbra; Rossi, Paolo; Sorino, Claudio; Steinhilber, Gundi; Zanforlin, Alessandro; Franzetti, Fabio; Carone, Mauro; Patella, Vincenzo; Scarlata, Simone; Comel, Andrea; Kurahashi, Kiyoyasu; Aoun Bacha, Zeina; Barajas Ugalde, Daniel; Ceballos Zuñiga, Omar; Villegas, José F.; Medenica, Milic; van de Garde, E. M. W.; Raj Mihsra, Deebya; Shrestha, Poojan; Ridgeon, Elliott; Ishola Awokola, Babatunde; Nwankwo, Ogonna N. O.; Olufunlola, Adefuye Bolanle; Olumide, Segaolu; Ukwaja, Kingsley N.; Irfan, Muhammad; Minarowski, Lukasz; Szymon, Skoczyński; Froes, Felipe; Leuschner, Pedro; Meireles, Mariana; Ferrão, Cláudia; Neves, João; Ravara, Sofia B.; Brocovschii, Victoria; Ion, Chesov; Rusu, Doina; Toma, Cristina; Chirita, Daniela; Dorobat, Carmen Mihaela; Birkun, Alexei; Kaluzhenina, Anna; Almotairi, Abdullah; Bukhary, Zakeya Abdulbaqi Ali; Edathodu, Jameela; Fathy, Amal; Mushira Abdulaziz Enani, Abdullah; Eltayeb Mohamed, Nazik; Ulhadi Memon, Jawed; Bella, Abdelhaleem; Bogdanović, Nada; Milenkovic, Branislava; Pesut, Dragica; Borderìas, Luis; Bordon Garcia, Noel Manuel; Cabello Alarcón, Hugo; Cilloniz, Catia; Torres, Antoni; Diaz-Brito, Vicens; Casas, Xavier; Encabo González, Alicia; Fernández-Almira, Maria Luisa; Gallego, Miguel; Gaspar-GarcÍa, Inmaculada; González Del Castillo, Juan; Javaloyes Victoria, Patricia; Laserna Martínez, Elena; Malo de Molina, Rosa; Menéndez, Rosario; Pando-Sandoval, Ana; Prat Aymerich, Cristina; Lacoma de la Torre, Alicia; García-Olivé, Ignasi; Rello, Jordi; Moyano, Silvia; Sanz, Francisco; Sibila, Oriol; Rodrigo-Troyano, Ana; Solé-Violán, Jordi; Uranga, Ane; van Boven, Job F. M.; Vendrell Torra, Ester; Pujol, Jordi Almirall; Feldman, Charles; Kee Yum, Ho; Fiogbe, Arnauld Attannon; Yangui, Ferdaous; Bilaceroglu, Semra; Dalar, Levent; Yilmaz, Ufuk; Bogomolov, Artemii; Elahi, Naheed; Dhasmana, Devesh J.; Feneley, Andrew; Hancock, Carole; Hill, Adam T.; Rudran, Banu; Ruiz-Buitrago, Silvia; Campbell, Marion; Whitaker, Paul; Youzguin, Alexander; Singanayagam, Anika; Allen, Karen S.; Brito, Veronica; Dietz, Jessica; Dysart, Claire E.; Kellie, Susan M.; Franco-Sadud, Ricardo A.; Meier, Garnet; Gaga, Mina; Holland, Thomas L.; Bergin, Stephen P.; Kheir, Fayez; Landmeier, Mark; Lois, Manuel; Nair, Girish B.; Patel, Hemali; Reyes, Katherine; Rodriguez-Cintron, William; Saito, Shigeki; Soni, Nilam J.; Noda, Julio; Hinojosa, Cecilia I.; Levine, Stephanie M.; Angel, Luis F.; Anzueto, Antonio; Scott Whitlow, K.; Hipskind, John; Sukhija, Kunal; Totten, Vicken; Wunderink, Richard G.; Shah, Ray D.; Mateyo, Kondwelani John; Carugati, Manuela; Morosi, Manuela; Monge, Elisa. - In: EUROPEAN JOURNAL OF INTERNAL MEDICINE. - ISSN 0953-6205. - (2018). [10.1016/j.ejim.2018.10.020]

An international perspective on hospitalized patients with viral community-acquired pneumonia

Sotgiu, Giovanni;
2018

Abstract

Background: Who should be tested for viruses in patients with community acquired pneumonia (CAP), prevalence and risk factors for viral CAP are still debated. We evaluated the frequency of viral testing, virus prevalence, risk factors and treatment coverage with oseltamivir in patients admitted for CAP. Methods: Secondary analysis of GLIMP, an international, multicenter, point-prevalence study of hospitalized adults with CAP. Testing frequency, prevalence of viral CAP and treatment with oseltamivir were assessed among patients who underwent a viral swab. Univariate and multivariate analysis was used to evaluate risk factors. Results: 553 (14.9%) patients with CAP underwent nasal swab. Viral CAP was diagnosed in 157 (28.4%) patients. Influenza virus was isolated in 80.9% of cases. Testing frequency and viral CAP prevalence were inhomogeneous across the participating centers. Obesity (OR 1.59, 95%CI: 1.01–2.48; p = 0.043) and need for invasive mechanical ventilation (OR 1.62, 95%CI: 1.02–2.56; p = 0.040) were independently associated with viral CAP. Prevalence of empirical treatment with oseltamivir was 5.1%. Conclusion: In an international scenario, testing frequency for viruses in CAP is very low. The most common cause of viral CAP is Influenza virus. Obesity and need for invasive ventilation represent independent risk factors for viral CAP. Adherence to recommendations for treatment with oseltamivir is poor.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/217482
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