Neurodegenerative disorders, including Amyotrophic Lateral Sclerosis (ALS), have been associated to alterations in chromatin structure resulting in long-lasting changes in gene expression. ALS is predominantly a sporadic disease and environmental triggers may be involved in its onset. In this respect, alterations in the epigenome can provide the key to transform the genetic information into phenotype. In this paper, we demonstrate that two modifications associated with transcriptional activation, namely dimethylation of lysine 4 on H3 tail (H3K4me2) and phospho-acetylation of serine 10 and lysine 14 on H3 tail (H3K14ac-S10ph), and two modifications associated to transcriptional repression, namely trimethylation of lysine 9 on H3 tail (H3K9me3) and DNA methylation are selectively altered in cellular and animal model of ALS. These results reinforce the idea that epigenetic therapy may represent a potential and attractive approach for ALS treatment.

Epigenetic changes associated with the expression of Amyotrophic Lateral Sclerosis (ALS) causing genes / Masala, Alessandra; Sanna, Simona; Esposito, Sonia; Rassu, Mauro; Galioto, Manuela; Zinellu, Angelo; Carru, Ciriaco; Carrì, Maria Teresa; Iaccarino, Ciro; Crosio, Claudia. - In: NEUROSCIENCE. - ISSN 0306-4522. - 390:(2018), pp. 1-11. [10.1016/j.neuroscience.2018.08.009]

Epigenetic changes associated with the expression of Amyotrophic Lateral Sclerosis (ALS) causing genes

Masala, Alessandra;Sanna, Simona;Esposito, Sonia;Rassu, Mauro;Galioto, Manuela;Zinellu, Angelo;Carru, Ciriaco;Carrì, Maria Teresa;Iaccarino, Ciro;Crosio, Claudia
2018-01-01

Abstract

Neurodegenerative disorders, including Amyotrophic Lateral Sclerosis (ALS), have been associated to alterations in chromatin structure resulting in long-lasting changes in gene expression. ALS is predominantly a sporadic disease and environmental triggers may be involved in its onset. In this respect, alterations in the epigenome can provide the key to transform the genetic information into phenotype. In this paper, we demonstrate that two modifications associated with transcriptional activation, namely dimethylation of lysine 4 on H3 tail (H3K4me2) and phospho-acetylation of serine 10 and lysine 14 on H3 tail (H3K14ac-S10ph), and two modifications associated to transcriptional repression, namely trimethylation of lysine 9 on H3 tail (H3K9me3) and DNA methylation are selectively altered in cellular and animal model of ALS. These results reinforce the idea that epigenetic therapy may represent a potential and attractive approach for ALS treatment.
2018
Epigenetic changes associated with the expression of Amyotrophic Lateral Sclerosis (ALS) causing genes / Masala, Alessandra; Sanna, Simona; Esposito, Sonia; Rassu, Mauro; Galioto, Manuela; Zinellu, Angelo; Carru, Ciriaco; Carrì, Maria Teresa; Iaccarino, Ciro; Crosio, Claudia. - In: NEUROSCIENCE. - ISSN 0306-4522. - 390:(2018), pp. 1-11. [10.1016/j.neuroscience.2018.08.009]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/215247
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 22
  • ???jsp.display-item.citation.isi??? 21
social impact