An Assessment of the Impact of Zidovudine on Rat Teeth Ontogenesis with Quantitative Laser Induced Fluorescence and an Histomorphological Analysis

Objectives: It is known that many conditions may impact on dental organ development at foetus or new-born stages. The most important infuence in this case is caused by genetic predispositions but also by drugs delivered prenatally and postnatally to the organism. The goal of this research was to find if the applications of Zidovudine to mothers’ organisms of rats can caused some abnormalities in dental organs of new-borns. Methods:The study was performed on 20 Wistar female rats and their 36 new-borns bred. The group of adult pregnant rats was divided on two sub-groups: with and without Zidovudine receiving. The infuence of Zidovudine administered was assessed by using the quantitative laser-induced fuorescence and compared with the group without Zidovudine receiving as a reference subjects. Results: In result the dependences in Zidovudine receiving were obtained and the changes in tissues were detected by use the laser fuorescence method. Moreover the differences between groups with and without Zidovudine are obtained in morphological results. The stronger impact of drug was obtained for mothers rats than new-borns. Conclusions: All obtained results show usefulness laser fuorescence in dental organ assessment.