Choosing the right biological target is the critical primary decision for the development of new drugs. Systematic genetic association testing of both human diseases and quantitative traits, along with resultant findings of coincident associations between them, is becoming a powerful approach to infer drug targetable candidates and generate in vitro tests to identify compounds that can modulate them therapeutically. Here we discuss opportunities and challenges and infer criteria for the optimal use of genetic findings in the drug discovery pipeline.
Genetic-driven druggable target identification and validation / Floris, Matteo; Olla, Stefania; Schlessigner, David; Cucca, Francesco. - In: TRENDS IN GENETICS. - ISSN 0168-9525. - 34:7(2018), p. 555. [10.1016/j.tig.2018.04.004]
Genetic-driven druggable target identification and validation
Matteo Floris;Francesco Cucca
2018-01-01
Abstract
Choosing the right biological target is the critical primary decision for the development of new drugs. Systematic genetic association testing of both human diseases and quantitative traits, along with resultant findings of coincident associations between them, is becoming a powerful approach to infer drug targetable candidates and generate in vitro tests to identify compounds that can modulate them therapeutically. Here we discuss opportunities and challenges and infer criteria for the optimal use of genetic findings in the drug discovery pipeline.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.