Transdermal fentanyl allows for consistent plasma concentrations of a potent synthetic µ-opioid receptor agonist and can provide constant post-operative analgesia for up to 72 h. The aim of this study was to determine the reduction of the minimum alveolar concentration of sevoflurane (MACSEVO) by transdermal fentanyl in non-pregnant ewes. Nine sheep were mask induced with SEVO in oxygen. MACSEVO determinations involved electrical current applied to the lateral metacarpus as a supramaximal stimulus and measurements in duplicate. Seven days later, a fentanyl patch (75 µg/h) was applied to each sheep and 15.1 ± 1.8 h later the MAC re-determined (MACSF). MACSF was 1.99 ± 0.32 %, corresponding to 25.6 ± 8.1 % reduction from MACSEVO (P < 0.001). Transdermal fentanyl produces a significant MACSEVO-sparing effect with minimal effect on cardiovascular parameters.

Mac-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep / Duffee, L.; Sanna Passino, E.; Scanu, A.; Columbano, N.. - In: ACTA VETERINARIA-BEOGRAD. - ISSN 0567-8315. - 68:2(2018), pp. 211-216. [10.2478/acve-2018-0015]

Mac-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep

Sanna Passino, E.;Columbano, N.
2018-01-01

Abstract

Transdermal fentanyl allows for consistent plasma concentrations of a potent synthetic µ-opioid receptor agonist and can provide constant post-operative analgesia for up to 72 h. The aim of this study was to determine the reduction of the minimum alveolar concentration of sevoflurane (MACSEVO) by transdermal fentanyl in non-pregnant ewes. Nine sheep were mask induced with SEVO in oxygen. MACSEVO determinations involved electrical current applied to the lateral metacarpus as a supramaximal stimulus and measurements in duplicate. Seven days later, a fentanyl patch (75 µg/h) was applied to each sheep and 15.1 ± 1.8 h later the MAC re-determined (MACSF). MACSF was 1.99 ± 0.32 %, corresponding to 25.6 ± 8.1 % reduction from MACSEVO (P < 0.001). Transdermal fentanyl produces a significant MACSEVO-sparing effect with minimal effect on cardiovascular parameters.
2018
Mac-Sparing Effect of Transdermal Fentanyl in Sevoflurane-Anesthetized Sheep / Duffee, L.; Sanna Passino, E.; Scanu, A.; Columbano, N.. - In: ACTA VETERINARIA-BEOGRAD. - ISSN 0567-8315. - 68:2(2018), pp. 211-216. [10.2478/acve-2018-0015]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/205153
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