Increased iron storage represents a characteristic condition in patients with beta zero-thalassaemia intermedia. Iron overload is an important factor in cellular damage. Recent studies have shown an enhanced lysosomal fragility due to increased iron storage. 13 patients with beta-thalassaemia intermedia, aged 17-44 years, were studied. Both serum ferritin and serum N-acetyl-beta-D-glucosaminidase levels were evaluated in all subjects studied. A significant linear correlation (P less than 0.05) between serum ferritin and serum N-acetyl-beta-D-glucosaminidase levels were found.

Iron overload and lysosomal stability in beta zero-thalassaemia intermedia and trait: correlation between serum ferritin and serum N-acetyl-beta-D-glucosaminidase levels / Frigerio, R; Mela, Q; Passiu, G; Cacace, E; La Nasa, G; Perpignano, G; Carcassi, U E. - In: SCANDINAVIAN JOURNAL OF HAEMATOLOGY. - ISSN 0036-553X. - 33:3(1984), p. 252-5.

Iron overload and lysosomal stability in beta zero-thalassaemia intermedia and trait: correlation between serum ferritin and serum N-acetyl-beta-D-glucosaminidase levels

Passiu, G;
1984

Abstract

Increased iron storage represents a characteristic condition in patients with beta zero-thalassaemia intermedia. Iron overload is an important factor in cellular damage. Recent studies have shown an enhanced lysosomal fragility due to increased iron storage. 13 patients with beta-thalassaemia intermedia, aged 17-44 years, were studied. Both serum ferritin and serum N-acetyl-beta-D-glucosaminidase levels were evaluated in all subjects studied. A significant linear correlation (P less than 0.05) between serum ferritin and serum N-acetyl-beta-D-glucosaminidase levels were found.
Iron overload and lysosomal stability in beta zero-thalassaemia intermedia and trait: correlation between serum ferritin and serum N-acetyl-beta-D-glucosaminidase levels / Frigerio, R; Mela, Q; Passiu, G; Cacace, E; La Nasa, G; Perpignano, G; Carcassi, U E. - In: SCANDINAVIAN JOURNAL OF HAEMATOLOGY. - ISSN 0036-553X. - 33:3(1984), p. 252-5.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/204189
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