Background Little is known about presenting âinconsistentâ or âpossibleâ usual interstitial pneumonia (UIP) computed tomography (CT) patterns advancing to âconsistentâ UIP as disease progresses in idiopathic pulmonary fibrosis (IPF). We hypothesized that if âconsistentâ UIP represented more advanced disease, such a pattern on presentation should also correlate with more severe pulmonary function test (PFT) abnormalities. Material and methods Consecutive IPF patients (2005â2013) diagnosed by international criteria with baseline PFT and CT were included. Presenting CTs were assessed by three expert radiologists for consensus UIP pattern (âconsistentâ, âpossibleâ, and âinconsistentâ). Approximation of individual and combined interstitial abnormalities was also performed with correlation of interstitial abnormalities and UIP CT pattern made with PFT findings and survival. Results Three-hundred and fifty patients (70% male) were included with a mean age of 68.3 years. Mean percent predicted forced vital capacity (FVC%) and diffusion capacity (DLCO%) was 64% and 45.5% respectively. Older age and male gender correlated more with âconsistentâ UIP CT pattern. FVC% was not associated with any UIP pattern but did correlate with total volume of radiologist assessed interstitial abnormalities. DLCO% was lower in those with âconsistentâ UIP pattern. A âconsistentâ UIP CT pattern was also not independently predictive of survival after correction for age, gender, FVC%, and DLCO%. Conclusion PFT findings appear to correlate with extent of radiologic disease but not specific morphologic patterns. Whether such UIP patterns represent different stages of disease severity or radiologic progression is not supported by coinciding pulmonary function decline.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
|Titolo:||Correlation of pulmonary function and usual interstitial pneumonia computed tomography patterns in idiopathic pulmonary fibrosis|
|Data di pubblicazione:||2017|
|Appare nelle tipologie:||1.1 Articolo in rivista|