Leptomeningeal carcinomatosis (LC) diagnosis is based on cerebrospinal fluid (CSF) cytological analysis and contrast-enhanced magnetic resonance imaging (MRI); however, low sensitivity was evidenced in some cases delaying prompt and adequate treatments. Brain18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) was also employed in doubtful cases. We retrospectively described 4 suspected LC cases with uncertain or undetectable MRI and initially negative CSF cytology. Whole-body (WB) and brain18F-FDG PET/computed tomography (CT) were used, the latter showing intracranial tracer uptakes suspected for LC in 3/4 cases. In 2 of these 3 cases, WB scan also evidenced spinal cord lesion and pulmonary tumor, respectively, while both procedures were true negative in the fourth case. CSF cytology became positive after repeated exams in the 3 PET/CT-positive cases. In 1 of these 3 patients, it was also confirmed at MRI, while it stayed negative in the remaining PET/CT-negative case with uncertain MRI.18F-FDG PET/CT could be a useful supportive diagnostic tool in doubtful intracranial and spinal LC.

Intracranial Leptomeningeal Carcinomatosis: A Diagnostic Study with18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography / Nuvoli, Susanna; Contu, Silvia; Pung, Bi Llie Joy; Solinas, Patrizia; Madeddu, Giuseppe; Spanu, Angela. - In: CASE REPORTS IN NEUROLOGY. - ISSN 1662-680X. - 10:1(2018), pp. 45-53. [10.1159/000486710]

Intracranial Leptomeningeal Carcinomatosis: A Diagnostic Study with18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography

Nuvoli, Susanna
;
Contu, Silvia;PUNG, Bi Llie Joy;Madeddu, Giuseppe;Spanu, Angela
2018

Abstract

Leptomeningeal carcinomatosis (LC) diagnosis is based on cerebrospinal fluid (CSF) cytological analysis and contrast-enhanced magnetic resonance imaging (MRI); however, low sensitivity was evidenced in some cases delaying prompt and adequate treatments. Brain18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) was also employed in doubtful cases. We retrospectively described 4 suspected LC cases with uncertain or undetectable MRI and initially negative CSF cytology. Whole-body (WB) and brain18F-FDG PET/computed tomography (CT) were used, the latter showing intracranial tracer uptakes suspected for LC in 3/4 cases. In 2 of these 3 cases, WB scan also evidenced spinal cord lesion and pulmonary tumor, respectively, while both procedures were true negative in the fourth case. CSF cytology became positive after repeated exams in the 3 PET/CT-positive cases. In 1 of these 3 patients, it was also confirmed at MRI, while it stayed negative in the remaining PET/CT-negative case with uncertain MRI.18F-FDG PET/CT could be a useful supportive diagnostic tool in doubtful intracranial and spinal LC.
Intracranial Leptomeningeal Carcinomatosis: A Diagnostic Study with18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography / Nuvoli, Susanna; Contu, Silvia; Pung, Bi Llie Joy; Solinas, Patrizia; Madeddu, Giuseppe; Spanu, Angela. - In: CASE REPORTS IN NEUROLOGY. - ISSN 1662-680X. - 10:1(2018), pp. 45-53. [10.1159/000486710]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/203083
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