This study presents a comparative analysis of the effects of different interferons tlFNJ on the three recognizable subsets of human HLA class II molecules: DR, BR, and DQ. Both cellular expression and shedding of class II molecules have been determined on three different cell type.*. The results can be summarized as follows: class II molecules are marked!~ increased by IFN gamma: IFN beta has a lower enhancing effect, and IFN alpha has only a slight, if any, effect. Kinetically, the action of IFN gamma is prompter and longer lasting than that of IFN beta. DQ expression is much more enhanced by IFN gamma than either DR or BR: IFN beta has the same effect on all three subsets. Parallel changes of the cellular expression and of the shedding of these molecules are observed. A melanoma and a lymphob/astoid cell line and perzpheral blood mononuclear cells show qualitatively similar modification

Differences in the expression and release of DR, BR, and DQ molecules in human cells treated with recombinant interferon gamma: comparison to other interferons / Capobianchi, Mr; Ameglio, F; Tosi, R; Dolei, A.. - In: HUMAN IMMUNOLOGY. - ISSN 0198-8859. - 13:1(1985), pp. 1-11.

Differences in the expression and release of DR, BR, and DQ molecules in human cells treated with recombinant interferon gamma: comparison to other interferons

Dolei A.
1985

Abstract

This study presents a comparative analysis of the effects of different interferons tlFNJ on the three recognizable subsets of human HLA class II molecules: DR, BR, and DQ. Both cellular expression and shedding of class II molecules have been determined on three different cell type.*. The results can be summarized as follows: class II molecules are marked!~ increased by IFN gamma: IFN beta has a lower enhancing effect, and IFN alpha has only a slight, if any, effect. Kinetically, the action of IFN gamma is prompter and longer lasting than that of IFN beta. DQ expression is much more enhanced by IFN gamma than either DR or BR: IFN beta has the same effect on all three subsets. Parallel changes of the cellular expression and of the shedding of these molecules are observed. A melanoma and a lymphob/astoid cell line and perzpheral blood mononuclear cells show qualitatively similar modification
Differences in the expression and release of DR, BR, and DQ molecules in human cells treated with recombinant interferon gamma: comparison to other interferons / Capobianchi, Mr; Ameglio, F; Tosi, R; Dolei, A.. - In: HUMAN IMMUNOLOGY. - ISSN 0198-8859. - 13:1(1985), pp. 1-11.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/202340
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