High serum levels of antibodies to interferon-gamma (IFN-gamma) have been found in patients infected with human immunodeficiency virus (HIV). A radioimmunoassay (RIA) with a recombinant IFN-gamma protein or an affinity purified IFN-gamma preparation as antigens, was developed to detect the specific anti-IFN-gamma antibodies. Reactivity of sera to IFN-gamma was confirmed by Western blot analysis. These antibodies, however, do not seem to recognize the active site of the molecule, since they do not neutralize the antiviral IFN-gamma activity in a biological assay. These results enforce the hypothesis of the role of autoimmunization during the course of the disease.

Anti-interferon-gamma antibodies in sera from HIV infected patients / Caruso, A; Foresti, I; Gribaudo, G; Bonfanti, C; Pollara, P; Dolei, A; Landolfo, S; Turano, A.. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - 3:1(1989), pp. 8-12.

Anti-interferon-gamma antibodies in sera from HIV infected patients

Dolei A;
1989

Abstract

High serum levels of antibodies to interferon-gamma (IFN-gamma) have been found in patients infected with human immunodeficiency virus (HIV). A radioimmunoassay (RIA) with a recombinant IFN-gamma protein or an affinity purified IFN-gamma preparation as antigens, was developed to detect the specific anti-IFN-gamma antibodies. Reactivity of sera to IFN-gamma was confirmed by Western blot analysis. These antibodies, however, do not seem to recognize the active site of the molecule, since they do not neutralize the antiviral IFN-gamma activity in a biological assay. These results enforce the hypothesis of the role of autoimmunization during the course of the disease.
Anti-interferon-gamma antibodies in sera from HIV infected patients / Caruso, A; Foresti, I; Gribaudo, G; Bonfanti, C; Pollara, P; Dolei, A; Landolfo, S; Turano, A.. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - 3:1(1989), pp. 8-12.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/202330
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