Background and aims We aimed to identify clusters of metabolic syndrome (MetS) components, risky for extremely high intima-media thickness. Methods We studied 41,513 volunteers (men and women) from eleven cohorts worldwide, participating in the MARE (Metabolic syndrome and Artery REsearch) Consortium. Results Specific clusters of MetS components - high triglycerides-high blood pressure-abdominal obesity (TBW), low HDL cholesterol-high blood pressure-abdominal obesity (HBW), high glucose-high blood pressure-abdominal obesity (GBW) - were accompanied by a 50â90% significantly greater likelihood of presenting extremely high intima-media thickness (via ultrasound of carotid artery, CCA IMT), after controlling for age, sex, smoking, non-HDL cholesterol, and presence of diabetes mellitus. This likelihood is comparable to the effect of being 7â8 years older or of being a cigarette smoker or of having non-HDL cholesterol 50 mg/dl higher. Conclusions The consistent association of specific clusters of MetS components with extremely thick (older) large artery cross-culturally suggests that identification of those clusters in clinical practice will facilitate a personalized health care and a better â i.e. more healthy and cost-effective - prevention of major cardiovascular (CV) events.
The relationship between the metabolic syndrome and arterial wall thickness: A mosaic still to be interpreted / Scuteri, A., Franco, O., Majiid, A., Jolita, B., Sergey, B., Cheng, H., Chen, C., Choi, S., Cucca, F., De Buyzere, M., Delitala, A., Marcus, D., Gunnar, E., Albert, H., Seul-Ki, J., Kweon, S., Michel, L., Lee, Y., Mattace Raso, F., Olle, M., et al.. - In: ATHEROSCLEROSIS. - ISSN 0021-9150. - 255:(2016), pp. 11-16. [10.1016/j.atherosclerosis.2016.10.032]
The relationship between the metabolic syndrome and arterial wall thickness: A mosaic still to be interpreted
Scuteri, A.
;Cucca, F.;Delitala, A.;
2016-01-01
Abstract
Background and aims We aimed to identify clusters of metabolic syndrome (MetS) components, risky for extremely high intima-media thickness. Methods We studied 41,513 volunteers (men and women) from eleven cohorts worldwide, participating in the MARE (Metabolic syndrome and Artery REsearch) Consortium. Results Specific clusters of MetS components - high triglycerides-high blood pressure-abdominal obesity (TBW), low HDL cholesterol-high blood pressure-abdominal obesity (HBW), high glucose-high blood pressure-abdominal obesity (GBW) - were accompanied by a 50â90% significantly greater likelihood of presenting extremely high intima-media thickness (via ultrasound of carotid artery, CCA IMT), after controlling for age, sex, smoking, non-HDL cholesterol, and presence of diabetes mellitus. This likelihood is comparable to the effect of being 7â8 years older or of being a cigarette smoker or of having non-HDL cholesterol 50 mg/dl higher. Conclusions The consistent association of specific clusters of MetS components with extremely thick (older) large artery cross-culturally suggests that identification of those clusters in clinical practice will facilitate a personalized health care and a better â i.e. more healthy and cost-effective - prevention of major cardiovascular (CV) events.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
