Brain abnormalities in neuromyelitis optica spectrum disorder (NMOSD) are highly heterogeneous and often non-specific. Extensive white matter involvement has been described and frequently manifests with encephalopathy requiring prompt intervention. Rarely, this may represent the only manifestation at onset without concurrent suggestive features of the disease, thus making diagnosis challenging. NMOSD may potentially occur at any age, but it seems that this disorder has distinctive clinical features in the elderly. We describe a case of NMOSD presenting as rapidly progressive leukoencephalopathy with atypical clinical and magnetic resonance imaging (MRI) findings in a 69-year-old woman.

Late presentation of NMOSD as rapidly progressive leukoencephalopathy with atypical clinical and radiological findings / Sechi, Elia; Addis, Alberto; Batzu, Lucia; Mariotto, Sara; Ferrari, Sergio; Conti, Maurizio; Sechi, Gianpietro. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 24:5(2017), pp. 685-688. [10.1177/1352458517721661]

Late presentation of NMOSD as rapidly progressive leukoencephalopathy with atypical clinical and radiological findings

Sechi, Elia
Project Administration
;
ADDIS, Alberto
Membro del Collaboration Group
;
Conti, Maurizio
Membro del Collaboration Group
;
Sechi, GianPietro
Membro del Collaboration Group
2017

Abstract

Brain abnormalities in neuromyelitis optica spectrum disorder (NMOSD) are highly heterogeneous and often non-specific. Extensive white matter involvement has been described and frequently manifests with encephalopathy requiring prompt intervention. Rarely, this may represent the only manifestation at onset without concurrent suggestive features of the disease, thus making diagnosis challenging. NMOSD may potentially occur at any age, but it seems that this disorder has distinctive clinical features in the elderly. We describe a case of NMOSD presenting as rapidly progressive leukoencephalopathy with atypical clinical and magnetic resonance imaging (MRI) findings in a 69-year-old woman.
Late presentation of NMOSD as rapidly progressive leukoencephalopathy with atypical clinical and radiological findings / Sechi, Elia; Addis, Alberto; Batzu, Lucia; Mariotto, Sara; Ferrari, Sergio; Conti, Maurizio; Sechi, Gianpietro. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 24:5(2017), pp. 685-688. [10.1177/1352458517721661]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/201228
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