An exploratory study of trace elements in ALS and their relationships with clinical severity was detected. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that causes irreversible damage in humans, with the consequent loss of function of motoneurons (MNs), with a prognosis up to 5 years after diagnosis. Except to genetic rare cases it is not known the etiology of the disorder. Aim of our research is to investigate the possible role of heavy metals in the severity of the disease. In this study, by the use of plasma mass (ICP-MS) , we have analyzed the content of essential and heavy metals such: Pb, Cd, Al, Hg, Mn, Fe, Cu, Zn, Se, Mg, and Ca, in blood, urine and hair of ALS patients and controls; moreover we divided the patients in two groups for disease severity and analyzed the difference among the groups, in order to study a possible involvement of metals in the severity of the damage. Our results suggest a protective role of Selenium, involved in protective antioxidant mechanisms, and a risk factor in the case of presence of Lead in blood. The levels of the other metals are not easy to interpret, because these may be due to life style and for essential metals a consequence of the disease condition, not a cause.
Trace elements in ALS patients and their relationships with clinical severity / Oggiano, Riccardo; Solinas, Maria Giuliana; Giovanni, Forte; Beatrice, Bocca; Farace, Cristiano; Pisano, Andrea; Sotgiu, Maria Alessandra; Simonetta, Clemente; Michele, Malaguarnera; Fois, Alessandro Giuseppe; Pirina, Pietro; Montella, Andrea Costantino Mario; Madeddu, Roberto Beniamino. - In: CHEMOSPHERE. - ISSN 0045-6535. - 197:(2018), pp. 457-466. [10.1016/j.chemosphere.2018.01.076]
Trace elements in ALS patients and their relationships with clinical severity
OGGIANO, Riccardo;Giuliana Solinas;Cristiano Farace;PISANO, Andrea;Maria Alessandra Sotgiu;Alessandro Giuseppe Fois;Pietro Pirina;Andrea Montella;Roberto Madeddu
2018-01-01
Abstract
An exploratory study of trace elements in ALS and their relationships with clinical severity was detected. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that causes irreversible damage in humans, with the consequent loss of function of motoneurons (MNs), with a prognosis up to 5 years after diagnosis. Except to genetic rare cases it is not known the etiology of the disorder. Aim of our research is to investigate the possible role of heavy metals in the severity of the disease. In this study, by the use of plasma mass (ICP-MS) , we have analyzed the content of essential and heavy metals such: Pb, Cd, Al, Hg, Mn, Fe, Cu, Zn, Se, Mg, and Ca, in blood, urine and hair of ALS patients and controls; moreover we divided the patients in two groups for disease severity and analyzed the difference among the groups, in order to study a possible involvement of metals in the severity of the damage. Our results suggest a protective role of Selenium, involved in protective antioxidant mechanisms, and a risk factor in the case of presence of Lead in blood. The levels of the other metals are not easy to interpret, because these may be due to life style and for essential metals a consequence of the disease condition, not a cause.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.