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Purpose: To report a case of clinically significant diabetic macula edema (DME) cured only with topical Betamethasone Sodium Phosphate, Tetracycline Hydrochloride and nonsteroidal anti-inflammatory drugs. Methods: A 44-year-old type I diabetic woman was referred to our Unit after a partial tarsorrhaphy procedure for exposure keratopathy in her left eye. OCT examination of her right eye revealed a clinically significant DME with important visual loss (Central Macular Thickness [CMT] 716 μm, Best Correct Visual Acuity [BCVA] 20/100 Snellen). The patient refused the suggested intravitreal therapy (Ranibizumab injections with PRN protocol). Topical treatment with Betamethasone Sodium Phosphate, Naphazoline Nitrate, Tetracycline Hydrochloride (Alfaflor®, Alfa Intest, Italy) and Diclofenac (Voltaren Oftabak®, Thea, France) eye-drops 4 times/day was started. Results: In the following 10 months, right CMT decreased to 335 μm and right BCVA increased to 20/25 Snellen. However, OCT scans still showed some intraretinal cysts. Topical Diclofenac was then replaced with Bromfenac (Yellox®, Bausch & Lomb, Italy) eye-drops 2 times/day. After 4 months’ treatment, right BCVA was 20/20 Snellen and OCT scans showed a normal CMT. This treatment was continued and there was no recurrence of DME in the next 11 months of follow-up. No adverse events were noted. Conclusions: Topical Betamethasone Sodium Phosphate and Tetracycline Hydrochloride, together with nonsteroidal anti-inflammatory eye-drops, might be an effective alternative for the treatment of newly diagnosed DME in patients not suitable for intravitreal therapy. Future case-control studies are necessary to confirm these results.

Topical betamethasone sodium phosphate, tetracycline hydrochloride and nonsteroidal anti-inflammatory drugs in the treatment of diabetic macular edema: a case report / D'AMICO RICCI, Giuseppe; Bouzios, Dimitrios; Boscia, Francesco; Pinna, Antonio. - In: ACTA OPHTHALMOLOGICA. - ISSN 1755-375X. - 95:S259(2017). [10.1111/j.1755-3768.2017.02316]

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