Human astrocyte cells were exposed to HIV-Tat and/or epidermal growth factor (EGF), to monitor the expression of the neuropathogenic MSRV and Syncytin-1 elements of the HERV-W family of endogenous retroviruses and of TNFα. The results indicate that EGF counteracts Tat regulation of HERV-W/MSRVenv/Syncytin-1, throughout EGFR activation; this effect occurs by interfering with the induction of TNFα production by Tat. The novel effect of EGF counteraction of Tat-mediated regulation of the neuropathogenic HERV-Ws could be neuro-protective, but its actual role in the brain remains to be elucidated.
The EGF epidermal growth factor counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes / Uleri, Elena; Piu, Claudia; Caocci, Maurizio; Ibba, Gabriele; Serra, Caterina; Dolei, Antonina. - In: JOURNAL OF NEUROVIROLOGY. - ISSN 1355-0284. - (2017), pp. 1-6. [10.1007/s13365-017-0531-2]
The EGF epidermal growth factor counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes
PIU, Claudia;IBBA, Gabriele;SERRA, Caterina;DOLEI, Antonina
2017-01-01
Abstract
Human astrocyte cells were exposed to HIV-Tat and/or epidermal growth factor (EGF), to monitor the expression of the neuropathogenic MSRV and Syncytin-1 elements of the HERV-W family of endogenous retroviruses and of TNFα. The results indicate that EGF counteracts Tat regulation of HERV-W/MSRVenv/Syncytin-1, throughout EGFR activation; this effect occurs by interfering with the induction of TNFα production by Tat. The novel effect of EGF counteraction of Tat-mediated regulation of the neuropathogenic HERV-Ws could be neuro-protective, but its actual role in the brain remains to be elucidated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.