Human astrocyte cells were exposed to HIV-Tat and/or epidermal growth factor (EGF), to monitor the expression of the neuropathogenic MSRV and Syncytin-1 elements of the HERV-W family of endogenous retroviruses and of TNFα. The results indicate that EGF counteracts Tat regulation of HERV-W/MSRVenv/Syncytin-1, throughout EGFR activation; this effect occurs by interfering with the induction of TNFα production by Tat. The novel effect of EGF counteraction of Tat-mediated regulation of the neuropathogenic HERV-Ws could be neuro-protective, but its actual role in the brain remains to be elucidated.

The EGF epidermal growth factor counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes / Uleri, Elena; Piu, Claudia; Caocci, Maurizio; Ibba, Gabriele; Serra, Caterina; Dolei, Antonina. - In: JOURNAL OF NEUROVIROLOGY. - ISSN 1355-0284. - (2017), pp. 1-6. [10.1007/s13365-017-0531-2]

The EGF epidermal growth factor counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes

PIU, Claudia;IBBA, Gabriele;SERRA, Caterina;DOLEI, Antonina
2017

Abstract

Human astrocyte cells were exposed to HIV-Tat and/or epidermal growth factor (EGF), to monitor the expression of the neuropathogenic MSRV and Syncytin-1 elements of the HERV-W family of endogenous retroviruses and of TNFα. The results indicate that EGF counteracts Tat regulation of HERV-W/MSRVenv/Syncytin-1, throughout EGFR activation; this effect occurs by interfering with the induction of TNFα production by Tat. The novel effect of EGF counteraction of Tat-mediated regulation of the neuropathogenic HERV-Ws could be neuro-protective, but its actual role in the brain remains to be elucidated.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/178103
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