Trichomonas vaginalis is a protozoan with an extracellular obligatory parasitic lifestyle exclusively adapted to the human urogenital tract and responsible for nearly a quarter billion sexually transmitted infections worldwide each year. This review focuses on symbiotic Trichomonasvirus and mycoplasmas carried by the protozoan, their molecular features and their role in altering the human vaginal microbiome and the immunopathogenicity of the parasite. Improved diagnostics and larger clinical interventional studies are needed to confirm the causative role of protozoan symbionts in the variable clinical presentation of trichomoniasis and its morbid sequelae, including adverse reproductive outcome, susceptibility to viral infections and cancer.

Trichomonas vaginalis infection in symbiosis with Trichomonasvirus and Mycoplasma / Fichorova, Raina; Fraga, Jorge; Rappelli, Paola; Fiori, Pier Luigi. - In: RESEARCH IN MICROBIOLOGY. - ISSN 0923-2508. - 168:9-10(2017), pp. 882-891. [10.1016/j.resmic.2017.03.005]

Trichomonas vaginalis infection in symbiosis with Trichomonasvirus and Mycoplasma

RAPPELLI, Paola;FIORI, Pier Luigi
2017-01-01

Abstract

Trichomonas vaginalis is a protozoan with an extracellular obligatory parasitic lifestyle exclusively adapted to the human urogenital tract and responsible for nearly a quarter billion sexually transmitted infections worldwide each year. This review focuses on symbiotic Trichomonasvirus and mycoplasmas carried by the protozoan, their molecular features and their role in altering the human vaginal microbiome and the immunopathogenicity of the parasite. Improved diagnostics and larger clinical interventional studies are needed to confirm the causative role of protozoan symbionts in the variable clinical presentation of trichomoniasis and its morbid sequelae, including adverse reproductive outcome, susceptibility to viral infections and cancer.
2017
Trichomonas vaginalis infection in symbiosis with Trichomonasvirus and Mycoplasma / Fichorova, Raina; Fraga, Jorge; Rappelli, Paola; Fiori, Pier Luigi. - In: RESEARCH IN MICROBIOLOGY. - ISSN 0923-2508. - 168:9-10(2017), pp. 882-891. [10.1016/j.resmic.2017.03.005]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/175156
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