The novel heteroleptic cyclometalated complex [AuIII(pyb-H)(mnt)] (1; pyb-H = C-deprotonated 2-benzylpyridine; mnt = 1,2-dicyanoethene-1,2-dithiolate) was tested against a panel of ten Gram positive (belonging to the Staphylococcus, Streptococcus spp. and Bacillus clausii), Gram negative (E. coli, K. pneumoniae, P. aeruginosa) bacteria and three yeasts belonging to the Candida spp. Complex 1 showed a remarkable bacteriostatic antimicrobial activity against staphylococci, with MinimumInhibitory Concentration (MIC) values of 1.56 and 3.13 μg/mL for S. haemoliticus and S. aureus, respectively. Spectroscopic and electrochemical measurements, supported by Density Functional Theory (DFT) calculations, were exploited to fully investigate the electronic structure of complex 1 and its relationship with the antimicrobial activity

[Au(pyb-H)(mnt)]: A novel gold(III) 1,2-dithiolene cyclometalated complex with antimicrobial activity (pyb-H = C-deprotonated 2-benzylpyridine; mnt = 1,2-dicyanoethene-1,2-dithiolate) / Pintus, Anna; Aragoni, M. Carla; Cinellu, Maria Agostina; Maiore, Laura; Isaia, Francesco; Lippolis, Vito; Orrù, Germano; Tuberi, Enrica; Zucca, Antonio; Arca, Massimiliano. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 170:(2017), pp. 188-194. [10.1016/j.jinorgbio.2017.02.015]

[Au(pyb-H)(mnt)]: A novel gold(III) 1,2-dithiolene cyclometalated complex with antimicrobial activity (pyb-H = C-deprotonated 2-benzylpyridine; mnt = 1,2-dicyanoethene-1,2-dithiolate)

CINELLU, Maria Agostina;MAIORE, Laura
;
ZUCCA, Antonio;
2017-01-01

Abstract

The novel heteroleptic cyclometalated complex [AuIII(pyb-H)(mnt)] (1; pyb-H = C-deprotonated 2-benzylpyridine; mnt = 1,2-dicyanoethene-1,2-dithiolate) was tested against a panel of ten Gram positive (belonging to the Staphylococcus, Streptococcus spp. and Bacillus clausii), Gram negative (E. coli, K. pneumoniae, P. aeruginosa) bacteria and three yeasts belonging to the Candida spp. Complex 1 showed a remarkable bacteriostatic antimicrobial activity against staphylococci, with MinimumInhibitory Concentration (MIC) values of 1.56 and 3.13 μg/mL for S. haemoliticus and S. aureus, respectively. Spectroscopic and electrochemical measurements, supported by Density Functional Theory (DFT) calculations, were exploited to fully investigate the electronic structure of complex 1 and its relationship with the antimicrobial activity
2017
[Au(pyb-H)(mnt)]: A novel gold(III) 1,2-dithiolene cyclometalated complex with antimicrobial activity (pyb-H = C-deprotonated 2-benzylpyridine; mnt = 1,2-dicyanoethene-1,2-dithiolate) / Pintus, Anna; Aragoni, M. Carla; Cinellu, Maria Agostina; Maiore, Laura; Isaia, Francesco; Lippolis, Vito; Orrù, Germano; Tuberi, Enrica; Zucca, Antonio; Arca, Massimiliano. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 170:(2017), pp. 188-194. [10.1016/j.jinorgbio.2017.02.015]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/174463
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