In implantology, as an alternative approach to the use of antibiotics, direct surface modifications of the implant addressed to inhibit bacterial adhesion and to limit bacterial proliferation are a promising tactic. The present study evaluates in an in vivo normal model the osteogenic response and the osteointegration of an anodic spark deposition nanostructured titanium surface doped with gallium (ASD + Ga) in comparison with two other surface treatments of titanium: an anodic spark deposition treatment without gallium (ASD) and an acid etching treatment (CTR). Moreover the study assesses the osteoprotective potential and the antibacterial effect of the previously mentioned surface treatments in an experimentally-induced peri-implantitis model. The obtained data points out a more rapid primary fixation in ASD and ASD + Ga implants, compared with CTR surface. Regarding the antibacterial properties, the ASD + Ga surface shows osteoprotective action on bone peri-implant tissue in vivo as well as an antibacterial effect within the first considered time point.

Osteogenic response and osteoprotective effects in vivo of a nanostructured titanium surface with antibacterial properties / Ravanetti, F; Chiesa, R.; Ossiprandi, M. C.; Gazza, F.; Farina, Vittorio; Martini, F. M.; Di Lecce, R.; Gnudi, G.; Della Valle, C.; Gavini, J.; Cacchioli, A.. - In: JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE. - ISSN 0957-4530. - 27:3(2016), pp. 1-15. [10.1007/s10856-015-5661-6]

Osteogenic response and osteoprotective effects in vivo of a nanostructured titanium surface with antibacterial properties

FARINA, Vittorio;
2016-01-01

Abstract

In implantology, as an alternative approach to the use of antibiotics, direct surface modifications of the implant addressed to inhibit bacterial adhesion and to limit bacterial proliferation are a promising tactic. The present study evaluates in an in vivo normal model the osteogenic response and the osteointegration of an anodic spark deposition nanostructured titanium surface doped with gallium (ASD + Ga) in comparison with two other surface treatments of titanium: an anodic spark deposition treatment without gallium (ASD) and an acid etching treatment (CTR). Moreover the study assesses the osteoprotective potential and the antibacterial effect of the previously mentioned surface treatments in an experimentally-induced peri-implantitis model. The obtained data points out a more rapid primary fixation in ASD and ASD + Ga implants, compared with CTR surface. Regarding the antibacterial properties, the ASD + Ga surface shows osteoprotective action on bone peri-implant tissue in vivo as well as an antibacterial effect within the first considered time point.
2016
Osteogenic response and osteoprotective effects in vivo of a nanostructured titanium surface with antibacterial properties / Ravanetti, F; Chiesa, R.; Ossiprandi, M. C.; Gazza, F.; Farina, Vittorio; Martini, F. M.; Di Lecce, R.; Gnudi, G.; Della Valle, C.; Gavini, J.; Cacchioli, A.. - In: JOURNAL OF MATERIALS SCIENCE. MATERIALS IN MEDICINE. - ISSN 0957-4530. - 27:3(2016), pp. 1-15. [10.1007/s10856-015-5661-6]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/173534
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