Technological properties and 'in vitro' dissolution pattern of some modified-release commercially available formulations, containing Diclofenac Sodium salt, were studied and compared. In experimental conditions similar to those in gastrointestinal tract, all examined preparations released more than 90% of their Diclofenac content. Comparative analysis of results, obtained whether from enteric coated or extended-release formulations, showed marked differences of drug dissolution rate depending on the pH of dissolution media.
CONTROLLO DELLE CARATTERISTICHE TECHNOLOGICHE E DELLA DISSOLUZIONE 'IN VITRO' DI DICLOFENAC DA COMPRESSE A RILASCIO MODIFICATO / Moretti, Mario Domenico Luigi; Mule', Antonio Calogero; Gavini, Elisabetta. - In: BOLLETTINO CHIMICO FARMACEUTICO. - ISSN 0006-6648. - 133:7(1994), pp. 465-472.
CONTROLLO DELLE CARATTERISTICHE TECHNOLOGICHE E DELLA DISSOLUZIONE 'IN VITRO' DI DICLOFENAC DA COMPRESSE A RILASCIO MODIFICATO
MORETTI, Mario Domenico Luigi;MULE', Antonio Calogero;GAVINI, Elisabetta
1994-01-01
Abstract
Technological properties and 'in vitro' dissolution pattern of some modified-release commercially available formulations, containing Diclofenac Sodium salt, were studied and compared. In experimental conditions similar to those in gastrointestinal tract, all examined preparations released more than 90% of their Diclofenac content. Comparative analysis of results, obtained whether from enteric coated or extended-release formulations, showed marked differences of drug dissolution rate depending on the pH of dissolution media.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
