In this paper we report the synthesis of a series of benzoxaborole derivatives, their inhibition properties against some carbonic anhydrases (CAs), recognized as important drug targets, and the characterization of the binding mode of these molecules to the CA active site. Our data provide the first experimental evidence that benzoxaboroles can be efficiently used as CA inhibitors.

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition / Alterio, Vincenzo; Cadoni, Roberta; Esposito, Davide; Vullo, Daniela; Fiore, Anna Di; Monti, Simona Maria; Caporale, Andrea; Ruvo, Menotti; Sechi, Mario; Dumy, Pascal; Supuran, Claudiu T.; Simone, Giuseppina De; Winum, Jean Yves. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 52:80(2016), pp. 11983-11986. [10.1039/c6cc06399c]

Benzoxaborole as a new chemotype for carbonic anhydrase inhibition

CADONI, Roberta;SECHI, Mario;
2016

Abstract

In this paper we report the synthesis of a series of benzoxaborole derivatives, their inhibition properties against some carbonic anhydrases (CAs), recognized as important drug targets, and the characterization of the binding mode of these molecules to the CA active site. Our data provide the first experimental evidence that benzoxaboroles can be efficiently used as CA inhibitors.
Benzoxaborole as a new chemotype for carbonic anhydrase inhibition / Alterio, Vincenzo; Cadoni, Roberta; Esposito, Davide; Vullo, Daniela; Fiore, Anna Di; Monti, Simona Maria; Caporale, Andrea; Ruvo, Menotti; Sechi, Mario; Dumy, Pascal; Supuran, Claudiu T.; Simone, Giuseppina De; Winum, Jean Yves. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 52:80(2016), pp. 11983-11986. [10.1039/c6cc06399c]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/168209
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