Auoxo3, a cytotoxic gold(III) compound, was encapsulated within a ferritin nanocage. Inductively coupled plasma mass spectrometry, circular dichroism, UV-Vis absorption spectroscopy and X-ray crystallography confirm the potential-drug encapsulation. The structure shows that naked Au(I) ions bind to the side chains of Cys48, His49, His114, His114 and Cys126, Cys126, His132, His147. The gold-encapsulated nanocarrier has a cytotoxic effect on different aggressive human cancer cells, whereas it is significantly less cytotoxic for non-tumorigenic cells.
Gold-based drug encapsulation within a ferritin nanocage: X-ray structure and biological evaluation as potential anticancer agent of the Auoxo3-loaded protein / Ferraro, Giarita; Monti, Daria Maria; Amoresano, Angela; Pontillo, Nicola; Petruk, Ganna; Pane, Francesca; Cinellu, Maria Agostina; Merlino, Antonello. - In: CHEMICAL COMMUNICATIONS. - ISSN 1359-7345. - 52:(2016), pp. 9518-9521. [10.1039/c6cc02516a]
Gold-based drug encapsulation within a ferritin nanocage: X-ray structure and biological evaluation as potential anticancer agent of the Auoxo3-loaded protein.
CINELLU, Maria Agostina;
2016-01-01
Abstract
Auoxo3, a cytotoxic gold(III) compound, was encapsulated within a ferritin nanocage. Inductively coupled plasma mass spectrometry, circular dichroism, UV-Vis absorption spectroscopy and X-ray crystallography confirm the potential-drug encapsulation. The structure shows that naked Au(I) ions bind to the side chains of Cys48, His49, His114, His114 and Cys126, Cys126, His132, His147. The gold-encapsulated nanocarrier has a cytotoxic effect on different aggressive human cancer cells, whereas it is significantly less cytotoxic for non-tumorigenic cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
