High stability of the complexes formed at physiological pH is one of the basic requisites that a good iron chelator must possess. At the same time the chelating agent must be selective toward iron, i.e., the stability of iron complexes must be significantly higher than that of the complexes formed with essential metal ions, in order that these last ones do not perturb iron chelation. In the frame of our research on iron chelators we have designed and synthesized a series of tetradentate derivatives of kojic acid, and examined their binding properties toward Fe3 + and Al3 +. In this paper, for a characterization of the behavior of the proposed iron chelating agents in biological fluids, their complex formation equilibria with copper(II) and zinc(II) ions have been fully characterized together with a speciation study, showing the degree at which the iron chelators interfere with the homeostatic equilibria of these two essential metal ions.

Zinc(II) and copper(II) complexes with hydroxypyrone iron chelators / Lachowicz, Joanna Izabela; Nurchi, Valeria Marina; Crisponi, Guido; Jaraquemada Pelaez, Maria De Guadalupe; Ostrowska, Małgorzata; Jezierska, Julia; Gumienna Kontecka, Elzbieta; Peana, Massimiliano Francesco; Zoroddu, Maria Antonietta; Choquesillo Lazarte, Duane; Niclós Gutiérrez, Juan; González Pérez, Josefa Maria. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 151:(2015), pp. 94-106. [10.1016/j.jinorgbio.2015.08.011]

Zinc(II) and copper(II) complexes with hydroxypyrone iron chelators

PEANA, Massimiliano Francesco;ZORODDU, Maria Antonietta;
2015

Abstract

High stability of the complexes formed at physiological pH is one of the basic requisites that a good iron chelator must possess. At the same time the chelating agent must be selective toward iron, i.e., the stability of iron complexes must be significantly higher than that of the complexes formed with essential metal ions, in order that these last ones do not perturb iron chelation. In the frame of our research on iron chelators we have designed and synthesized a series of tetradentate derivatives of kojic acid, and examined their binding properties toward Fe3 + and Al3 +. In this paper, for a characterization of the behavior of the proposed iron chelating agents in biological fluids, their complex formation equilibria with copper(II) and zinc(II) ions have been fully characterized together with a speciation study, showing the degree at which the iron chelators interfere with the homeostatic equilibria of these two essential metal ions.
Zinc(II) and copper(II) complexes with hydroxypyrone iron chelators / Lachowicz, Joanna Izabela; Nurchi, Valeria Marina; Crisponi, Guido; Jaraquemada Pelaez, Maria De Guadalupe; Ostrowska, Małgorzata; Jezierska, Julia; Gumienna Kontecka, Elzbieta; Peana, Massimiliano Francesco; Zoroddu, Maria Antonietta; Choquesillo Lazarte, Duane; Niclós Gutiérrez, Juan; González Pérez, Josefa Maria. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 151:(2015), pp. 94-106. [10.1016/j.jinorgbio.2015.08.011]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/165970
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