Metals have strong toxic effects in humans and can act as immunoregulatory factors. The purpose of our study was to determine whether the concentrations of metals are associated with the clinical course of nasal polyposis (NP). We measured the concentrations of 10 metals and non-metal (Zn, Mn, Se, Fe, Cr, Ni, Pb, Al, Cd, and Cu) in 58 patients with NP, and 29 controls with a healthy nasal mucosa. We used electron microscopy to compare the ultrastructural features of the nasal mucosa between NP patients and healthy controls. Concentrations of metals in nasal polyps and healthy mucosa were determined by mass spectrometry. Transmission electron microscopic (TEM) and scanning electron microscopic (SEM) images of the nasal mucosa were obtained. The mean tissue concentrations of all 10 metals and non-metal were significantly lower in NP patients than in healthy controls (P < 0.05).TEM and SEM revealed changes in the mucosal ultrastructure in NP with progressive fibrosis, devascularisation, and inflammation. Tissue concentrations of metals were lower in NP patients than in healthy controls, and this was particularly evident in massive polyposis.

Influence of metals on rhinosinusal polyposis in Sardinian population (Italy) / Asara, Yolande; Melis, Andrea; DE LUCA, Laura Maria; Bozzo, Corrado Pasquale; Castiglia, Paolo Giuseppino; Chessa, Giannina; Piras, Patrizia; Karligkiotis, Apostolos; Bandiera, Pasquale; Malaguarnera, Michele; Marchal, Juan Antonio; Madeddu, Roberto Beniamino. - In: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH INTERNATIONAL. - ISSN 0944-1344. - (2016). [10.1007/s11356-016-7406-6]

Influence of metals on rhinosinusal polyposis in Sardinian population (Italy)

ASARA, Yolande;MELIS, Andrea;DE LUCA, Laura Maria;BOZZO, Corrado Pasquale;CASTIGLIA, Paolo Giuseppino;KARLIGKIOTIS, Apostolos;BANDIERA, Pasquale;MADEDDU, Roberto Beniamino
2016

Abstract

Metals have strong toxic effects in humans and can act as immunoregulatory factors. The purpose of our study was to determine whether the concentrations of metals are associated with the clinical course of nasal polyposis (NP). We measured the concentrations of 10 metals and non-metal (Zn, Mn, Se, Fe, Cr, Ni, Pb, Al, Cd, and Cu) in 58 patients with NP, and 29 controls with a healthy nasal mucosa. We used electron microscopy to compare the ultrastructural features of the nasal mucosa between NP patients and healthy controls. Concentrations of metals in nasal polyps and healthy mucosa were determined by mass spectrometry. Transmission electron microscopic (TEM) and scanning electron microscopic (SEM) images of the nasal mucosa were obtained. The mean tissue concentrations of all 10 metals and non-metal were significantly lower in NP patients than in healthy controls (P < 0.05).TEM and SEM revealed changes in the mucosal ultrastructure in NP with progressive fibrosis, devascularisation, and inflammation. Tissue concentrations of metals were lower in NP patients than in healthy controls, and this was particularly evident in massive polyposis.
Influence of metals on rhinosinusal polyposis in Sardinian population (Italy) / Asara, Yolande; Melis, Andrea; DE LUCA, Laura Maria; Bozzo, Corrado Pasquale; Castiglia, Paolo Giuseppino; Chessa, Giannina; Piras, Patrizia; Karligkiotis, Apostolos; Bandiera, Pasquale; Malaguarnera, Michele; Marchal, Juan Antonio; Madeddu, Roberto Beniamino. - In: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH INTERNATIONAL. - ISSN 0944-1344. - (2016). [10.1007/s11356-016-7406-6]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/165512
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