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Humans are exposed to carcinogenic nickel (Ni) compounds both occupationally and environmentally. In this paper, molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of the uptake of nickel sulfide particles in cells, their dissolution and their effects on heterochromatin. Molecular mechanisms by which nickel induces gene silencing, DNA hypermethylation and inhibition of histone acetylation, will be discussed. © 2002 Elsevier Science Ireland Ltd. All rights reserved.

Molecular mechanisms of nickel carcinogenesis / Cangul, H.; Broday, L.; Salnikow, K.; Sutherland, J.; Peng, W.; Zhang, Q.; Poltaratsky, V.; Yee, H.; Zoroddu, Maria Antonietta; Costa, M.. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - 127:1-3(2002), pp. 69-75. [10.1016/S0378-4274(01)00485-4]

Molecular mechanisms of nickel carcinogenesis

ZORODDU, Maria Antonietta;
2002-01-01

Abstract

Humans are exposed to carcinogenic nickel (Ni) compounds both occupationally and environmentally. In this paper, molecular mechanisms of nickel carcinogenesis are considered from the point-of-view of the uptake of nickel sulfide particles in cells, their dissolution and their effects on heterochromatin. Molecular mechanisms by which nickel induces gene silencing, DNA hypermethylation and inhibition of histone acetylation, will be discussed. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
2002
Molecular mechanisms of nickel carcinogenesis / Cangul, H.; Broday, L.; Salnikow, K.; Sutherland, J.; Peng, W.; Zhang, Q.; Poltaratsky, V.; Yee, H.; Zoroddu, Maria Antonietta; Costa, M.. - In: TOXICOLOGY LETTERS. - ISSN 0378-4274. - 127:1-3(2002), pp. 69-75. [10.1016/S0378-4274(01)00485-4]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/165433
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