Copper(II) complexes of carvedilol molecule, (carvH): 1-[carbazolyl-(4)-oxyl]-3-[(2-methoxyphenoxyethyl)-amino]-2-propanol, were synthesized and characterized with respect to their structural and spectroscopic properties. The crystal structure of [Cu(Carv)Cl(MeOH)]2·4MeOH complex revealed that the molecule chelates two Cu(II) ions via the N and O atoms belonging to the amino and propanol moiety, respectively. The coordination behaviour of carvedilol studied by 1H nuclear magnetic resonance (NMR, 1-D and 2-D-COSY) spectroscopy in dimethyl sulfoxide solution at room temperature, allowed us to obtain structural information and to identify the donor atoms involved in the coordination process in solution. © 2003 Elsevier Science Inc. All rights reserved.

Carvedilol, a β adrenoceptor blocker with chelating properties. A copper 'superdimer' based on dimetal units / Zoroddu, Maria Antonietta; Grepioni, Fabrizia; Franconi, Flavia. - In: JOURNAL OF INORGANIC BIOCHEMISTRY. - ISSN 0162-0134. - 95:4(2003), pp. 315-320. [10.1016/S0162-0134(03)00130-2]

Carvedilol, a β adrenoceptor blocker with chelating properties. A copper 'superdimer' based on dimetal units

ZORODDU, Maria Antonietta;FRANCONI, Flavia
2003

Abstract

Copper(II) complexes of carvedilol molecule, (carvH): 1-[carbazolyl-(4)-oxyl]-3-[(2-methoxyphenoxyethyl)-amino]-2-propanol, were synthesized and characterized with respect to their structural and spectroscopic properties. The crystal structure of [Cu(Carv)Cl(MeOH)]2·4MeOH complex revealed that the molecule chelates two Cu(II) ions via the N and O atoms belonging to the amino and propanol moiety, respectively. The coordination behaviour of carvedilol studied by 1H nuclear magnetic resonance (NMR, 1-D and 2-D-COSY) spectroscopy in dimethyl sulfoxide solution at room temperature, allowed us to obtain structural information and to identify the donor atoms involved in the coordination process in solution. © 2003 Elsevier Science Inc. All rights reserved.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11388/165431
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