The present work furnishes an innovative preparation of substituted indoles based on tandem hydroformylation, where the chemo- and the regio-selectivities are good, so the yield of the reaction. The novelty has been established in the four-step transformation of substituted alpha nitrocinnamaldehydes into desired indoles in a one-pot reaction. Under hydroformylation reaction conditions we have been able to trigger off a cascade of reactions, which gave substituted indoles in high yields. Useful intermediates are prepared by using this technique for the synthesis of well-known biologically active molecules. © 2008 Elsevier B.V. All rights reserved.

Synthesis of indole derivatives by domino hydroformylation/indolization of 2-nitrocinnamaldehydes / Marchetti, Mauro; Paganelli, S.; Carboni, Davide; Ulgheri, Fausta; Del Ponte, G.. - In: JOURNAL OF MOLECULAR CATALYSIS. A: CHEMICAL. - ISSN 1381-1169. - 288:1-2(2008), pp. 103-108. [10.1016/j.molcata.2008.03.025]

Synthesis of indole derivatives by domino hydroformylation/indolization of 2-nitrocinnamaldehydes

MARCHETTI, Mauro;CARBONI, Davide;ULGHERI, Fausta;
2008-01-01

Abstract

The present work furnishes an innovative preparation of substituted indoles based on tandem hydroformylation, where the chemo- and the regio-selectivities are good, so the yield of the reaction. The novelty has been established in the four-step transformation of substituted alpha nitrocinnamaldehydes into desired indoles in a one-pot reaction. Under hydroformylation reaction conditions we have been able to trigger off a cascade of reactions, which gave substituted indoles in high yields. Useful intermediates are prepared by using this technique for the synthesis of well-known biologically active molecules. © 2008 Elsevier B.V. All rights reserved.
2008
Synthesis of indole derivatives by domino hydroformylation/indolization of 2-nitrocinnamaldehydes / Marchetti, Mauro; Paganelli, S.; Carboni, Davide; Ulgheri, Fausta; Del Ponte, G.. - In: JOURNAL OF MOLECULAR CATALYSIS. A: CHEMICAL. - ISSN 1381-1169. - 288:1-2(2008), pp. 103-108. [10.1016/j.molcata.2008.03.025]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/162866
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