Nickel compounds are included among human carcinogens, though the molecular events related to them are not yet completely known.It has been proposed that the basic element, in the mechanism of carcinogenesis exerted by nickel, is connected to its binding within the cell nucleus. DNA can weakly bind Ni(II), thus the nuclear proteins, in particular histones proteins which are abundantly present, could be important targets for Ni(II) ions.The present review describes the interactions of nickel with histone H4, core tetramer (H3-H4)2 and several peptide fragments which have been selected as possible candidates for specific binding sites in the histone octamer.The collected results allowed us to propose several mechanisms for nickel-induced damage triggering from metal coordination, including structural changes of histone proteins, as well as nucleobase oxidation and sequence-specific histone hydrolysis.
Nickel binding sites in histone proteins: Spectroscopic and structural characterization / Peana, Massimiliano Francesco; Medici, Serenella; Nurchi, Vm; Crisponi, G; Zoroddu, Maria Antonietta. - In: COORDINATION CHEMISTRY REVIEWS. - ISSN 0010-8545. - 257:19-20(2013), pp. 2737-2751. [10.1016/j.ccr.2013.02.022]
Nickel binding sites in histone proteins: Spectroscopic and structural characterization
PEANA, Massimiliano Francesco;MEDICI, Serenella;ZORODDU, Maria Antonietta
2013-01-01
Abstract
Nickel compounds are included among human carcinogens, though the molecular events related to them are not yet completely known.It has been proposed that the basic element, in the mechanism of carcinogenesis exerted by nickel, is connected to its binding within the cell nucleus. DNA can weakly bind Ni(II), thus the nuclear proteins, in particular histones proteins which are abundantly present, could be important targets for Ni(II) ions.The present review describes the interactions of nickel with histone H4, core tetramer (H3-H4)2 and several peptide fragments which have been selected as possible candidates for specific binding sites in the histone octamer.The collected results allowed us to propose several mechanisms for nickel-induced damage triggering from metal coordination, including structural changes of histone proteins, as well as nucleobase oxidation and sequence-specific histone hydrolysis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.