The interaction of the potent anti-diabetic agent bis(maltolato)-oxidovanadium(IV) (BMOV) with some proteins of blood serum was studied by EPR spectroscopy, pH-potentiometry and DFT calculations. The formation of cis-VO(ma)(2)(hTf), cis-VO(ma)(2)(HSA) and cis-VO(ma)(2)(IgG), their role in the biotransformation in vivo and the mechanism of transport of BMOV in blood are discussed.
Biotransformation of BMOV in the presence of blood serum proteins / Sanna, D.; Bíró, L.; Buglyó, P.; Micera, Giovanni; Garribba, Eugenio. - In: METALLOMICS. - ISSN 1756-5901. - 4:1(2012), pp. 33-36. [10.1039/c1mt00161b]
Biotransformation of BMOV in the presence of blood serum proteins
GARRIBBA, Eugenio
2012-01-01
Abstract
The interaction of the potent anti-diabetic agent bis(maltolato)-oxidovanadium(IV) (BMOV) with some proteins of blood serum was studied by EPR spectroscopy, pH-potentiometry and DFT calculations. The formation of cis-VO(ma)(2)(hTf), cis-VO(ma)(2)(HSA) and cis-VO(ma)(2)(IgG), their role in the biotransformation in vivo and the mechanism of transport of BMOV in blood are discussed.File in questo prodotto:
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