The ability of the docking program AutoDock in studying the binding of small molecules to DNA is examined. Herein, we report molecular dynamic studies with the relaxed complex method applied to DNA, and viscosimetric titration results, performed to investigate a possible DNA-binding mode of a model compound of the previously reported “two armed” class of binders.

Molecular Recognition of DNA by 2,3,6,7-tetrahydro-1H-pyrrolo[1,2-a]indole-1,8(5H)-dione bis(4,5-dihydro-1H-imidazol-2-ylhydrazone) as a Prototype of “Two-Armed” Intercalating Agents / Dallocchio, R; Dessì, A; Sanna, Vanna Annunziata; Pala, N; Campesi, Ilaria; Paglietti, G. Sechi M.. - In: LETTERS IN DRUG DESIGN & DISCOVERY. - ISSN 1570-1808. - 6:4(2009), pp. 246-251. [10.2174/157018009788452537]

Molecular Recognition of DNA by 2,3,6,7-tetrahydro-1H-pyrrolo[1,2-a]indole-1,8(5H)-dione bis(4,5-dihydro-1H-imidazol-2-ylhydrazone) as a Prototype of “Two-Armed” Intercalating Agents.

SANNA, Vanna Annunziata;CAMPESI, Ilaria;
2009-01-01

Abstract

The ability of the docking program AutoDock in studying the binding of small molecules to DNA is examined. Herein, we report molecular dynamic studies with the relaxed complex method applied to DNA, and viscosimetric titration results, performed to investigate a possible DNA-binding mode of a model compound of the previously reported “two armed” class of binders.
2009
Molecular Recognition of DNA by 2,3,6,7-tetrahydro-1H-pyrrolo[1,2-a]indole-1,8(5H)-dione bis(4,5-dihydro-1H-imidazol-2-ylhydrazone) as a Prototype of “Two-Armed” Intercalating Agents / Dallocchio, R; Dessì, A; Sanna, Vanna Annunziata; Pala, N; Campesi, Ilaria; Paglietti, G. Sechi M.. - In: LETTERS IN DRUG DESIGN & DISCOVERY. - ISSN 1570-1808. - 6:4(2009), pp. 246-251. [10.2174/157018009788452537]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11388/150321
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