In pursuing earlier studies, the synthesis of a series of 1 and 1,3- substituted 2-(4-chloro-3-sulfamoylbenzamido)isoindolines (V a-e), related to indapamide, is described. These compounds were evaluated for diuretic and antihypertensive activities.
Diuretic agents related to indapamide. II. Synthesis and pharmacological activity of 1-alkyl, 1-carboxyalkyl- and 1,3-dialkyl substituted 2-(4-chloro-3-sulfamoylbenzamido)isoindolines / Sanna P; Cignarella G; Anania V; Siri R; Desole M.S.. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - 40:10(1985), pp. 777-785.